Tamara Minko

Professor II and Chair

Department of Pharmaceutics

Publications

Selected from over 400 publications including journal research articles, book and textbook chapters, abstracts/conference proceedings and patents.

  1. V. Shah, O. Taratula, O. B. Garbuzenko, M. L. Patil, R. Savla, M. Zhang, T. Minko, Genotoxicity of nanocarriers with different composition, architecture, size, molecular weight and charge, Current Drug Discovery Technologies, 2012 May 4. [Epub ahead of print].
  2. M. Zhang, O. B. Garbuzenko, K. R. Reuhl, L. Rodriguez-Rodriguez, T. Minko, Two-in-one: combined targeted chemo and gene therapy for tumor suppression and prevention of metastases, Nanomedicine (Lond), 7, 185-197 (2012).
  3. O. Taratula, O. B. Garbuzenko, A. M. Chen, T. Minko, “Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA, J. Drug Target., 19, 900-914 (2011).
  4. R. Savla, O. Taratula, O. B. Garbuzenko, T. Minko, Targeted, pH-sensitive quantum dot delivery of doxorubicin for treatment of ovarian cancer, J. Control. Release, 153, 16-22 (2011).
  5. S. Betigeri, M. Zhang, O. Garbuzenko, T. Minko, Non-viral delivery of siRNA or antisense oligonucleotides targeted to Jun N-Terminal Kinase 1 prevents cellular hypoxic damage, Drug Deliv. and Transl. Res., 1, 13–24 (2011).
  6. O. Taratula, R. Savla, H. He, T. Minko, Poly(propyleneimine) dendrimers as potential siRNA delivery nanocarrier: from structure to function, Int. J. Nanotechnology 8, 36 – 52 (2011).
  7. O. Taratula, R. Savla, Y. A. Wang, H. He, T. Minko, Multifunctional nanomedicine platform for cancer specific delivery of siRNA by supermagnetic iron oxide nanoparticles/dendrimer complexes, Curr. Drug Delivery, 8, 59-69 (2011).
  8. N. Dayan, V. Shah, T. Minko, Genotoxic potential evaluation of a cosmetic insoluble substance by the micronuclei assay, J. Cosmet. Sci., 62, 29-39 (2011).
  9. N. Dayan, V. Shah, T. Minko, Preliminary evaluation of the genotoxic potential of a hydrophilic polymer with three preservation systems, Int J Cosmet Sci, 33, 497-502 (2011).
  10. P. Chandna, J. J. Khandare, E. Ber, L. Rodriguez-Rodriguez, T. Minko, Targeted multicomponent polymer-peptide-drug conjugates for treatment of primary and metastatic cancers, Pharm. Res., 27, 2296-2306 (2010).
  11. O. B. Garbuzenko, M. Saad, V. P. Pozharov, K. R. Reuhl, G. Mainelis, T. Minko. New horizons in treatment of lung cancer: Combinatorial local inhalatory delivery of drugs and suppressors of cellular resistance, Proc. Natl. Acad. Sci. USA, 107, 10737-10742 (2010).
  12. A. M. Chen, O. Taratula, D. Wei, H.-I. Yen, T. Thomas, T. J. Thomas, T. Minko, H. He, Labile Catalytic Packaging of DNA siRNA: Control of Gold Nanoparticles out of DNA siRNA Complexes, ACS Nano, 4, 3679-3688 (2010).
  13. T. Minko, HPMA copolymers for modulating cellular signaling and overcoming multidrug resistance, Adv. Drug Deliver. Rev., 62, 192-202 (2010).
  14. T. Minko, M. L. Patil, M. Zhang, J. J. Khandare, M. Saad, P. Chandna, O. Taratula, LHRH-targeted nanoparticles for cancer therapeutics, Methods Mol Biol., 624, 281-294 (2010).
  15. A. M. Chen, M. Zhang, D. Wei, D. Stueber, O. Taratula, T. Minko, H. He, Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug Resistant Cancer Cells, Small, 5, 2673-2677 (2009). 
  16. O. Taratulaa, O. B. Garbuzenko, P. Kirkpatrick, I. Pandya, R. Savlaa, V. P. Pozharov, H. He, T. Minko, Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery, J. Control. Release, 140, 284-293 (2009). 
  17. D. Christian, S. Cai, O. Garbuzenko, T. Harada, A. Zajac, T. Minko, D. Discher, Flexible Filaments for in vivo Imaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage, Mol Pharm., 6, 1343-1352 (2009). 
  18. Z. Keresztessy, M. Bodnar, E. Ber, I. Hajdu, M. Zhang, J. F. Hartmann, T. Minko, J. Borbely, Self-Assembling Chitosan/Poly-?-Glutamic Acid Nanoparticles for Targeted Drug Delivery, Colloid and Polymer Science, 287, 759-765 (2009)
  19. M. L. Patil, M. Zhang, O. Taratula, H. He, T. Minko, Internally Cationic Polyamidoamine PAMAM-OH Dendrimers for siRNA Delivery: Effect of the Degree of Quaternization and Cancer Targeting, Biomacromolecules, 10, 258-266 (2009).
  20. O. B. Garbuzenko, M. Saad, S. Betigeri, M. Zhang, A. A. Vetcher, V. A. Soldatenkov, D. C. Reimer, T. Minko, Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug, Pharm. Research, 26, 382-394 (2009).
  21. M. Saad, O. B. Garbuzenko, T. Minko, Co-delivery of siRNA and an anticancer drug for treatment of multidrug resistant cancer, Nanomedicine, 3, 761-776 (2008).
  22. M. Saad, O. B. Garbuzenko, E. Ber, P. Chandna, J. J. Khandare, V. P. Pozharov, T. Minko, Receptor - targeted nanocarriers for tumor specific treatment and imaging, J. Control. Release, 130, 107-114 (2008).
  23. M. L. Patil, M. Zhang, S. Betigeri, O. Taratula, H. He, T. Minko, Surface Modified and Internally Cationic Polyamidoamine Dendrimers for Efficient siRNA Delivery, Bioconjugate Chem., 19, 1396-403 (2008).
  24. Y. Wang, M. Saad, R. I. Pakunlu, J. J. Khandare, O. B. Garbuzenko, A. A. Vetcher, V. A. Soldatenkov, V. P. Pozharov, T. Minko, Non-viral nanoscale-based delivery of antisense oligonucleotides targeted to HIF1 alpha enhances the efficacy of chemotherapy in drug resistant tumor, Clin. Cancer Res., 14, 3607-3616 (2008).
  25. T. Minko, J. J. Khandare, A. A. Vetcher, V. A. Soldatenkov, O. B. Garbuzenko, M. Saad, V. P. Pozharov, Multifunctional nanotherapeutics for cancer (Chapter 10), In.: Multifunctional Pharmaceutical Nanocarriers, V. P. Torchilin, Ed., Springer, 2008, pp. 309-335.
  26. Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari, T. Minko, D. E. Discher, Shape effects of filaments versus spherical particles in flow and drug delivery, Nature Nanotech., 2, 249 – 255 (2007).
  27. P. Chandna, M. Saad, E. Ber, J. J. Khandare, A. A. Vetcher, V. A. Soldatenkov, T. Minko, LHRH receptor targeting of polymer therapeutics to tumor, Mol. Pharm., 4,668-678 (2007).
  28. S. Jayant, J. J. Khandare, Y. Wang, A. P. Singh, N. Vorsa, T. Minko, Targeted Sialic Acid - Doxorubicin Prodrugs for Intracellular Delivery and Cancer Treatment, Pharm. Res., 24, 2120-2130 (2007).
  29. S. Zalipsky, M. Saad, R. Kiwan, E. Ber, N. Yu, T. Minko, Antitumor activity of new liposomal prodrug of Mitomycin C in multidrug resistant solid tumor: Insights of the mechanism of action, J. Drug Target., 15, 518-530 (2007).
  30. T. Minko, Intracellular delivery, Pharm. Res., 24, 2097-2098 (2007).
  31. T. Minko, J. J. Khandare, S. Jayant, Polymeric Drugs (Chapter 14), In.: Macromolecular Engineering: From Precise Macromolecular Synthesis to Macroscopic Material Properties and Application, Volume 4, K. Matyjaszewski, Y. Gnanou, L. Leibler, Eds., WILEY-VCH Verlag GmbH & Co., 2007, pp. 2541-2595.
  32. J. J. Khandare, T. Minko, Antibodies and peptides in cancer therapy, Crit. Rev. Ther. Drug Carrier Syst., 23, 401-435 (2006).
  33. J. J. Khandare, S. Jayant, A. Singh, P. Chandna, Y. Wang, N. Vorsa, T. Minko, Dendrimer versus linear conjugate: influence of polymeric architecture on the delivery and anticancer effect of paclitaxel, Bioconjugate Chem., 17, 1464-1472 (2006).
  34. J. J. Khandare, P. Chandna, Y. Wang, V. P. Pozharov, T. Minko, Novel polymeric prodrug with multivalent components for cancer therapy, J. Pharmacol. Exp. Ther., 317, 929-937 (2006).
  35. J. J. Khandare, T. Minko, Polymer-drug conjugates: Progress in polymeric prodrugs, Prog. Polym. Sci., 31, 359-397 (2006).
  36. S. S. Dharap, P. Chandna, Y. Wang, J. J. Khandare, B. Qiu, S. Stein, T. Minko, Molecular targeting of BCL2 and BCLXL proteins by synthetic BH3 peptide enhances the efficacy of chemotherapy, J. Pharmacol. Exp. Ther. 316, 992-998 (2006).
  37. T. Minko, R. I. Pakunlu, Y. Wang, J. J. Khandare, M. Saad, New generation of liposomal drugs for cancer, Anticancer Agents Med. Chem., 6, 537-552 (2006).
  38. R. I Pakunlu, Y. Wang, M. Saad, J. J. Khandare, V. Starovoytov, T. Minko, In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug, J. Controlled Rel., 114, 153-162 (2006).
  39. S. Betigeri, R.I. Pakunlu, Y. Wang, J.J. Khandare, T. Minko, JNK1 as a molecular target to limit cellular mortality under hypoxia, Mol. Pharm., 3, 424-430 (2006).
  40. F. Ahmed, R. I. Pakunlu, A. Brannan, F. Bates, T. Minko, D. E. Discher, Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors by inducing apoptosis in proportion to accumulated drug, J. Controlled Rel., 116, 150-158 (2006).
  41. F. Ahmed, R. I. Pakunlu, G. Srinivas, A. Brannan, F. Bates, M. L. Klein, T. Minko, D. E. Discher, Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation, Mol. Pharm, 3, 340-350 (2006).
  42. T. Minko, Hypoxia-induced lung damage and alpha tocopherol, In.: The Encyclopedia of Vitamin E, V. R. Preedy and R. Watson, Eds, CAB International, 2006, pp. 699-708.
  43. T. Minko, Chapter 22, Drug delivery systems, In: Martin’s Physical Pharmacy and Pharmaceutical Sciences 5th Edition, P. J. Sinko, Ed., Lippincott Williams and Wilkins, 2006, pp. 629-680.
  44. T. Minko, Chapter 17, Colloids, In: Martin’s Physical Pharmacy and Pharmaceutical Sciences 5th Editionn, P. J. Sinko, Ed., Lippincott Williams and Wilkins, 2006, pp. 469-498.
  45. T. Minko, Chapter 16, Interfacial Phenomena, In: Martin’s Physical Pharmacy and Pharmaceutical Sciences 5th Editionn, P. J. Sinko, Ed., Lippincott Williams and Wilkins, 2006, pp. 437-467.
  46. S. S. Dharap, Y. Wang, P. Chandna, J. J. Khandare, B. Qiu, S. Gunaseelan, P. J. Sinko, S. Stein, A. V. Farmanfarmanian, T. Minko, Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide, Proc. Natl. Acad. Sci. USA, 102, 12962-12967 (2005).
  47. D. Yu, P. Peng, S. S. Dharap, Y. Wang, M. Mehlig, P. Chandna, H. Zhao, D. Filpula, K. Yang, V. Borowski, G. Borchard, Z. Zhang, T. Minko, Antitumor activity of poly(ethylene glycol) – camptothecin conjugate: the inhibition of tumor growth in vivo, J. Controlled Rel., 110, 90-102 (2005).
  48. T. Minko, Soluble polymer conjugates for drug delivery, Drug Discovery Today, 2, 15-20 (2005).
  49. T. Minko, Y. Wang, V. Pozharov, Remediation of cellular hypoxic damage by pharmacological agents, Curr. Pharm. Des., 11, 3185-3199 (2005).
  50. T. Minko, E. V. Batrakova, S. Li, Y. Li, R. I. Pakunlu, V. Yu. Alakhov, A. V. Kabanov, Pluronic Block Copolymer Formulation with Doxorubicin Induces Apoptosis in Drug-Resistant Cancer Cells, J. Controlled Rel., 105, 269-278 (2005).
  51. T. Minko. Mechanisms of cellular drug resistance and strategies to overcome it, In: Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids, R. I. Mahato, Ed, CRC Press, Boca Raton, London, New York, Washington, D.C., 2005, pp. 461-492.
  52. Y. Wang, T. Minko, A novel cancer therapy: Liposomal hypoxia inducible factor 1 alpha antisense oligonucleotides in combination with hypoxia and doxorubicin, Biochem. Pharmacol., 68, 2031-2042 (2004).
  53. R. I. Pakunlu, Y. Wang, W. Tsao, V. Pozharov, T. J. Cook, T. Minko, Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system, Cancer Research, 64, 6214-6224 (2004).
  54. T. Minko, S. S. Dharap, R. I. Pakunlu, Y. Wang, Molecular targeting of drug delivery systems to cancer, Curr. Drug Targets, 5, 389-406 (2004).
  55. Y. Wang, R. I. Pakunlu, W. Tsao, V. Pozharov, T. Minko, Bimodal effect of hypoxia in cancer: the role of hypoxia inducible factor in apoptosis, Mol. Pharm., 1, 156-165 (2004).
  56. T. Minko, Drug targeting to the colon with lectins and neoglycoconjugates, Adv. Drug Deliver. Rev., 56, 491-509 (2004).
  57. A. David, P. Kopeckova, T. Minko, A, Rubinstein, J. Kopecek, The involvement of endogenous lectins in mediating the antitumor activity of targetable HPMA copolymer-doxorubicin conjugates in human colon adenocarcinoma and hepatocarcinoma cells, Eur. J. Cancer, 40, 148-157 (2004).
  58. S. S. Dharap, B. Qiu, G. Williams, P. J. Sinko, S. Stein, T. Minko, Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides, J. Controlled Rel., 91, 61-73 (2003).
  59. T. Minko, S. S. Dharap, A. T. Fabbricatore, Enhancing the efficacy of chemotherapeutic drugs by the suppression of antiapoptotic cellular defense, Cancer Detect. Prev., 27, 193-202 (2003).
  60. S. S. Dharap, T. Minko, Targeted proapoptotic LHRH-BH3 peptide, Pharm. Res., 20, 889-896 (2003).
  61. R. I. Pakunlu, T. J. Cook, T. Minko, Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin, Pharm. Res., 20, 351-359 (2003).
  62. T. Minko, A. Stefanov, V. Pozharov, Lung hypoxia: Antioxidant and antiapoptotic effects of liposomal alpha tocopherol, J. Appl. Physiol., 93, 1550-1560 (2002).

Department of Pharmaceutics, Ernest Mario School of Pharmacy

Rutgers, The State University of New Jersey
160-Frelinghuysen Road, Piscataway, NJ 08854-8022, USA.
Tel: (732) 445-3831*214; Fax: (732) 445-3134
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