MSB News

October 3 , 2007
Charlie Roth presented a seminar entitled "Engineering Intracellular Delivery of Oligonucleotides" at Hoffman LaRoche.

September 29 , 2007
We were well represented at this week's BMES Conference in Los Angeles (Holloywood), CA. Salaheldin Hamed, Ronn Friedlander , and Charlie Roth each presented posters detailing our recent research findings.

September 22 , 2007
Our paper "Quantitative Measurements and Rational Materials Design for Intracellular Delivery of Oligonucleotides", byCharles M. Roth, was published in Biotechnology Progress (2007; Epub Sept. 22).

September 21 , 2007
BME senior Ronn Friedlander has received funding from the Aresty Research Center for Undergraduates. This award will support Ronn's travel to the upcoming BMES Conference, where his abstract was accepted for presentation.

September 1 , 2007
Our paper "Effects of Retinoic Acid on Proliferation and Differentiation of HepG2 Cells", by Michelle Burley and Charles M. Roth, was published in Open Biotechnology Journal (2007; 1:47-51).

July 16, 2007
Sumati Sundaram defended her dissertation today, entitled "Interplay of Polymer and Oligonucleotide Properties in the Nature of Antisense Effects". Sumati is the first Ph.D. to graduate from the group. Congratulations, Sumati!

June 18 , 2007
Our paper "Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity", by Sumati Sundaram, Li Kim Lee, and Charles M. Roth, was published online in Nucleic Acids Research (2007; 35:4396-4408).

June 6 , 2007
Welcome to the newest member of our group! Dr. Vidya Iyer joins us as a postodoctoral associate. Vidya recently finished her Ph.D. in Chemical Engineering from Iowa State and will be co-advised by Marianthi Ierapetritou.

May 17, 2007
Congratulations to our seniors, Mark Hwang and Clare Tang, who graduated with BS degrees in Biomedical Engineering, and to Jeffrey Ly, who graduated with an MS in Biomedical Engineering today. Clare is doing an industrial intership this summer and will return to Rutgers in Fall as part of her BS/MS program, Mark will be starting the MD/PhD program at U. of Illinois at Urbana-Champaign and Jeffrey will begin work at Merck. Best wishes in your future endeavors!

May 8 , 2007
Hong Yang successfully defended her thesis proposal entitled "Reaction and Pathway Analysis of Hepatic Metabolism."

April 18, 2007
Jeffrey Ly successfully defended his his MS paper entitled "Poly(propylacrylic acid) mediated delivery of antisense oligonucleotides ". Best of luck to Jeffrey, who will receive his MS this May and be joining Merck.

March 14 , 2007
Charlie Roth presented a seminar entitled "Molecular Design and Cellular Delivery of Oligonucleotides" in the Department of Biomedical Engineering at City College of New York.

February 22 , 2007
Salaheldin Hamed successfully defended his thesis proposal entitled "Correlating Gene Expression with Resistance to Chemotherapy in Glioma Cell Lines".

February 7 , 2007
Charlie Roth presented a seminar entitled "Molecular Design and Cellular Delivery of Oligonucleotides" at Pfizer Global Research and Development in St. Louis.

January 1, 2007
Our research group continues to grow! Juan Lagos has joined us as a part-time Ph.D. student in the Department of Chemical and Biochemical Engineering. When he's not with us, Juan holds down a full-time job at Schering-Plough.

November 28, 2006
Welcome to three new members of the research group! Nimish Gupta comes from IIT-Madras and is co-advised by Prof. Marianthi Ierapetritou. Dominik Naczynski completed his undergraduate degree at Cornell and is co-advised by Prof. Prabhas Moghe. Carolyn Waite completed her degree at Lafayette College and is a trainee in the IGERT Training Program on Nanopharmaceutics. Nimish, Dom and Carolyn are all first-year students in the Department of Chemical and Biochemical Engineering.

November 22 , 2006
Our paper "Cellular dynamics of antisense oligonucleotides and short interfering RNAs", by Li Kim Lee, Brandee M. Dunham, Zhuting Li , and Charles M. Roth, was published in Annals of the N.Y. Academy of Sciences (2006; 1082:47-51).

November 15 , 2006
Michelle Burley has been awarded a Technology Fellowship by the New Jersey Commission on Science and Technology. This postdoctoral fellowship will support her work at Germgard Lighting Corporation.

November 15 , 2006
Michelle Burley, Stephen Guzikowski, Sumati Sundaram, and Hong Yang represented Rutgers at the American Institute of Chemical Engineers conference in San Francisco this week. Michelle presented a poster entitled "Retinoic acid induced changes in hepatocyte morphology and function". Stephen spoke on "Metabolic and genomic analysis of acetaminophen metabolism and induced-hepatotoxicity", Sumati on "Interplay of polymer and DNA properties on the dynamics of antisense inhibition ", and Hong on "Reaction and pathway analysis of hepatic metabolism".

November 8 , 2006
A paper describing the IGERT Biointerfaces curriculum, "Multidisciplinary graduate curriculum on integrative biointerfacial engineering", by Prabhas V. Moghe , and Charles M. Roth, was published in Chemical Engineering Education (2006; 40:251-258).

October 14 , 2006
Salaheldin Hamed, Mark Hwang, and Sumati Sundaram represented us at the Biomedical Engineering Society conference in Chicago this week. Salah presented a poster entitled "Relationship of chemotherapeutic dose-response curves to cell cycle effects" and Sumati on "Interplay of polymer and DNA properties on the dynamics of antisense activity ", while Mark made an oral presentation on "Interplay of polymer and nucleic acid properties on antisense effectiveness".

September 18 , 2006
BME senior Mark Hwang has received funding from the Aresty Research Center for Undergraduates. This award will support Mark's travel to the upcoming BMES Conference, where his abstract was accepted for oral presentation.

September 14 , 2006
Stephen Guzikowski and Sumati Sundaram represented Rutgers at the American Chemical Society conference in San Francisco this week. Stephen spoke on "Metabolic and genomic analysis of acetaminophen metabolism and induced-hepatotoxicity" and Sumati on "Role of vector in the dynamics of antisense activity".

Sepember 1, 2006
Jeffrey Ly has joined the group as a Masters degree candidate in Biomedical Engineering. He will join the Oligonucleotide Delivery research team.

July 12 , 2006
Professor Prabhas Moghe received an NSF Nanoscale Interdisciplinary Research Team (NIRT) award. The award, which is $1M for 4 years, is from a project entitled “Ligand Nanodisplay for Cell Cytointernalization and SuperActivation”. Prof. Moghe is the PI of the team comprised of Professors Roth, Tsakalakos, and Talaga from Rutgers and Prof. Schwarzbauer (Princeton).

June 23, 2006
Charlie Roth has been awarded a 2-year, $25,000 award from the Charles and Johanna Busch Memorial Fund to support a research project entitled "Inhibition of DNA Repair Using Short Interfering RNA in Glioma Cells"

June 6, 2006
Lavanya Peddada has been awarded a graduate training fellowship in the Rutgers-NSF IGERT on Integratively Engineered Biointerfaces. Lavanya is working on the development of peptide-based biomaterials to direct oligonucleotides into and within cells to their mRNA targets.

June 5, 2006
Welcome to our visiting summer students! Kimberly Argen joins us from Cooper Union, where she will be a senior next year in Engineering with a biomechanical emphasis, and is co-advised by Prof. Marianthi Ierapetritou. Camil Aponte joins us as part of the RISE and ISURF programs. Camil is a mathematics major at U. of Puerto Rico, Rio Piedras and is co-advised by Prof. Stan Dunn.

June 2, 2006
Sumati Sundaram represented Rutgers at the 19th Annual Meeting of Mid-Atlantic Biochemical Engineering Consortium, giving a talk on "The role of vector in the dynamics of antisense activity".

May 18, 2006
Congratulations to our seniors -- Amit Misra, Rashmeet Sangari, Samuel Tischfield, and David Wayman -- who all graduated today. Best wishes in your future endeavors!

May 12, 2006
Our paper on "Poly(propylacrylic acid) enhances cationic lipid-mediated delivery of antisense oligonucleotides", by Li Kim Lee, Charity L. Williams, David Devore, and Charles M. Roth, was published in Biomacromolecules (2006 May;7(5):1502-8).

April 6, 2006
Charlie Roth was promoted to Associate Professor with Tenure.

April 1, 2006
Sumati Sundaram and Stephen Guzikowski gave presentations at the 32nd Northeast Bioengineering Conference in Easton, PA. Sumati gave an oral presentation on "The role of vector in the dynamics of antisense activity" and Stephen gave a poster presentation entitled "Modeling Regulatory and Metabolic Mechanisms for Acetaminophen-induced Hepatotoxicity".