UMDNJ-Rutgers University
CounterACT Research
Center of Excellence

Designing therapies to counteract chemical terrorism.

Joshua P. Gray, Ph.D.

Assistant Professor
Chemistry
Department of Science
United States Coast Guard Academy

Email: joshua.p.gray@uscga.edu
Room: 308 Smith Hall
Phone: 860-444-8636
Fax: 860-701-6147
Web page

B.S. Biochemistry & Molecular Biology, Pennsylvania State University
Ph.D. Pathobiology, Pennsylvania State University
Postdoctoral, Mechanisms of Oxidative Stress, UMDNJ-Robert Wood Johnson Medical School

Education & Training Core, UMDNJ-Rutgers University CounterACT Center of Excellence

Research Interests:

Mechanisms of dermatoxicity, wound healing, cell growth regulation, peroxisome proliferators, role of redox cycling in chemical toxicity, reactive oxygen intermediates, paraquat toxicity, microsensors in toxicity, toxicogenomics.

Recent Publications:

Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD (2010). Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci 114: 5-19 (PMC2819970). [abstract]

Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD. (2010). Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes.  Free Radic Biol Med 48:1485-1491. [abstract]

Jan YH, Heck DE, Gray JP, Zheng H, Casillas RP, Laskin DL, Laskin JD (2010). Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Chem Res Toxicol 23:1045-1053. [abstract]

Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD (2010). Inhibition of NADPH cytochrome  P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species. Toxicol Appl Pharmacol 247: 76-82 (PMC Journal - In Process). [abstract]

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, and Laskin JD (2008). "Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes." Carcinogenesis 29(1): 219-25. [abstract]

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, and Laskin JD (2008). "Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat." Toxicol Appl Pharmacol 231(3): 384-92. [abstract]

Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, and Laskin JD (2008). "UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes." Toxicol Appl Pharmacol 232(1): 14-24. [abstract]

Gray JP, Heck DE, Mishin V, Smith PJS, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD (2007). Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H: Paraquat Oxidoreductase: Identification of the enzyme as thioredoxin reductase. (2007) J Biol Chem 282(11): 7939-7949. [abstract]

Copyright © 2008 Joshua P. Gray