The literature on vesicating agents may provide important clues that will lead to the development of effective countermeasures. The reference library outlined below is an important component of our CounterACT Education and Training program run by Drs. Joshua Gray and Diane Heck. You can search using filters and download citations directly into EndNote and other popular literature citation formats. Click here to access the online database.
References cataloged by subject:
Recent Publications by the UMDNJ/Rutgers University CounterACT Center Investigators
2011
Sunil VR, Patel-Vayas K, Shen J, Gow AJ, Laskin JD, Laskin DL. (2011) Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 250(3):245-255. [abstract]
Sunil VR, Patel KJ, Shen J, Reimer D, Gow AJ, Laskin JD, Laskin DL. (2011) Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 250(1):10-18. [abstract]
Young SC, Fabio KM, Huang, MT, Saxena J, Harman MP, Guillon CD, Vetrano AM, Heck DE, Flowers RA, Heindel ND, Laskin JD (2011) Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation. J. Applied Toxicology, published online 2/11/11. [abstract]
Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE, Laskin DL. (2011) Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther. 24(1):92-99.
Anumolu SS, Menjoge AR, Deshmukh M, Gerecke D, Stein S, Laskin J, Sinko PJ (2011). Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries, Biomaterials. 32(4):1204-1217. [abstract]
Laskin DL, Gardner, C, Sunil VR, Laskin JD. (2011) Macrophages and tissue injury. Agents of defense or destruction? Annu Rev Pharmacol Toxicol. 51:267-288. [abstract]
2010
Kutscher HL, Chao P, Deshmukh M, Sundara Rajan S, Singh Y, Hu P, Joseph LB, Stein S, Laskin DL, Sinko PJ. (2010) Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats. Int J Pharm. 402(1-2):64-71. [abstract]
Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL, Laskin JD (2010). Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci 114: 5-19 (PMC2819970). [abstract]
Mishin V, Gray JP, Heck DE, Laskin DL, Laskin JD. (2010). Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 48:1485-1491. [abstract]
Laskin JD, Black AT, Jan YH, Sinko PJ, Heindel ND, Sunil V, Heck DE, Laskin DL (2010). Oxidants and antioxidants in sulfur mustard-induced injury Ann NY Acad Sci 1203: 92-100. [abstract]
Black AT, Joseph LB, Casillas RP, Heck DE, Sinko PJ, Gerecke DR, Laskin DL, Laskin JD (2010). Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol 245: 352-360. [abstract]
Jan YH, Heck DE, Gray JP, Zheng H, Casillas RP, Laskin DL, Laskin JD (2010). Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Chem Res Toxicol 23:1045-1053. [abstract]
Young S, Fabio K, Guillon C, Mohanta P, Halton TA, Heck DE, Flowers RA , Laskin JD, Heindel ND (2010). Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. Bioorg Med Chem Lett 20: 2987-2990. [abstract]
Malaviya R, Sunil VR, Cervelli J, Anderson DR, Holmes WW, Conti ML, Gordon RE, Laskin JD, Laskin DL (2010). Inflammatory effects of inhaled sulfur mustard in rat lungs. Toxicol Appl Pharmacol. 248(2):89-99. [abstract]
Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD (2010). Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species. Toxicol Appl Pharmacol 247: 76-82 (PMC Journal - In Process). [abstract]
Black AT, Hayden PJ, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD (2010). Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol. 249(2):178-187. [abstract]
Chao P, Deshmukh M, Kutscher HL, Gao D, Tajan SS, Hu P, Laskin DL, Stein S, Sinko PJ (2010). Pulmonary targeting microparticulate CPT delivery system: anti-cancer evaluation in a rat orthotopic lung cancer model. Anticancer Drugs 21: 65-76. [abstract]
Kutscher HL, Chao P, Deshmukh M, Singh Y, Hu P, Joseph LB, Reimer DC, Laskin DL, Sinko PJ. (2010). Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. J Control Release. 1: 31-37. [abstract]
Anumolu SS, DeSantis AS, Hahn RA, Beloni JA, Menjoge AR, Gordon MK, Sinko PJ. (2010). Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds. Biomaterials 31: 964-974. [abstract]
Gordon MK, Hahn RA (2010). Collagens. Cell Tissue Res 339: 247-257.
Deshmukh M, Singh Y, Gunaseelan S, Gao D, Stein S, Sinko PJ. (2010) Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism, Biomaterials, 31: 6675-6684. [abstract]
Gordon MK, DeSantis A, Deshmukh M, Lacey CJ, Hahn RA, Beloni J, Anumolu SS, Schlager JJ, Gallo MA, Heindel N, Gerecke DR, Svoboda KH, Babin M, Sinko PJ (2010) Doxycycline hydrogels as a potential therapy for ocular vesicant injury. J Ocul Pharmacol Ther. 26(5):407-419. [abstract]
2009 and older
Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang Y-C, Tong W, Androulakis IP, Georgopoulos PG (2009). Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicol Appl Pharmacol 234:156-165. [abstract]
Anumolu SS, Singh Y, Gao D, Stein S, Sinko PJ, (2009) Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. Journal of Controlled Release, 2009. 137(2):152-159. (PMC2694223) [abstract]
Deshmukh, M, Kutscher H, Stein S, P. Sinko PJ, (2009) Nonenzymatic, self-elimination degradation mechanism of glutathione. Chem Biodivers. 6(4):527-539. [abstract]
Laskin DL (2009). Macrophages and inflammatory mediators in chemical toxicity: friends or foe? Chem Res Toxicol 22: 1376-1385. (PMC2787782) [abstract]
Chang YC, Sabourin CLK, Lu SE, Sasaki T, Svoboda KH, Gordon MK, Riley DJ, Casillas RP, Gerecke DR (2009). Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. J Biochem Molec Toxicol 23:172-184. [abstract]
Svoboda KK, Fischman DA, Gordon MK. (2008) Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions. Dev Dyn. 237: 2667-2675. [abstract]
Gerecke DR, Sabourin CLK, Chang YC, Laskin JD, Gordon MK, Casillas RP (2007). Gene expression profiles of vesicant-induced skin injury. Proceedings of the HFM Symposium on Defense Against the Effects of Chemical Hazards: Toxicology, Diagnosis, and Medical Countermeasures. RTO-MP-HFM-149, 5:1-12.
Reviews and Book Chapters
Laskin DL, Sunil VR, Fakhrzadeh L, Groves A, Gow AJ, Laskin JD. (2010) Macrophages, reactive nitrogen species, and lung injury. Ann N Y Acad Sci. 1203:60-65.
Gordon MK, Enzenauer RW, Babin M (2009). Ocular toxicity of sulfur mustard, in: Handbook of the Toxicology of Chemical Warfare Agents (Gupta, RC, ed.), Elsevier Academic Press, Burlington, MA, pp. 575-594.
Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, Slikker W. (2009) Nitrative and oxidative stress in toxicology and disease. Toxicol Sci. 112(1):4-16.
Laskin JD, Heck DE, Laskin DL (2010) Nitric oxide pathways in toxic responses, General and Applied Toxicology, third edition. B. Ballantyne, T. Marrs, T. Syversen, eds. UK: Wiley-Blackwell, pp. 425-438.
Laskin DL, Laskin JD (2010) Inflammation and Cancer, Holland-Frei’s- Cancer Medicine, 8th edition, W.K. Hong, R.C. Bast, W.N. Hait, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei, eds., New York: PMPH Publishing House, chapter 19, pp. 270-278.
Laskin DL, Gardner CR, Laskin JD, (2010) “Phagocytes”, in: Comprehensive Toxicology, Volume 5, Toxicology of the Immune System. C. McQueen, ed., Elsevier, NY, pp. 133-153.
Gerecke DR, Gray JP, Shakarjian MP, Casillas RP (2008). Dermal toxicity of sulfur mustard, in: Handbook of Toxicology of Chemical Warfare Agents (Gupta, RC, ed.), Elsevier Academic Press, Kidlington, Oxford, UK, 611-633.
