Dr. Temple is studying how embryonic neural progenitor cells generate the numerous,
diverse, cell types of the adult CNS. These studies may lead to therapies for
neurodegenerative disorders or for neural tumors.
Dr.Temple has designed a culture
system in which single CNS progenitor cells can divide and differentiate into clones
of neurons and glial cells. This led to the identification of different classes of
progenitor cells in embryonic forebrain, including one that may play a key role
in brain development: multipotential stem cells.
Molecular mechanisms regulating
division and differentiation of brain progenitor cells will be the focus of
future studies.
Resent publications*
Qian X, Goderie SK, Shen Q, Stern JH, Temple S Intrinsic programs of patterned cell
lineages in isolated vertebrate CNS ventricular zone cells. Development 1998 Aug;125(16):3143-52
Shen Q, Qian X, Capela A, Temple S Stem cells in the embryonic cerebral cortex: their role in
histogenesis and patterning. J Neurobiol 1998 Aug;36(2):162-74
Qian X, Davis AA, Goderie SK, Temple S FGF2 concentration regulates the generation of
neurons and glia from multipotent cortical stem cells. Neuron 1997 Jan;18(1):81-93
Davis AA, Temple S A self-renewing multipotential stem cell in embryonic rat cerebral cortex.
Nature 1994 Nov 17;372(6503):263-6
Temple S, Alvarez-Buylla A Stem cells in the adult mammalian central nervous system. Curr
Opin Neurobiol 1999 Feb;9(1):135-41
