Seminar Series - August 5, 2005

Elaine Fuchs, Ph.D

Elaine Fuchs's research abstract*:

Elaine Fuchs is interested in understanding the molecular mechanisms underlying the ability of multipotent stem cells to produce the skin’s epidermis and its appendages. She utilizes mammalian epithelial stem cell culture and mouse genetics as model systems. Her studies bridge an understanding of the normal biology of skin stem cells with an understanding of how these processes go awry in human diseases of the skin, including genetic diseases and skin cancer.

Selected Publications*:

Blanpain, C., Lowry W.E., Geoghegan A., Polak, L. and Fuchs, E. "Self renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche." Cell 118, 635-648 (2004).

Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. "Defining the epithelial stem cell niche of the skin." Science, [Published on-line Science Express Dec 11, 2003] Science 303, 359-363 (2004).

Kobielak A, Pasolli HA and Fuchs E. "Mammalian formin1 participates in adherens junctions and polymerization of linear actin cables." Nature Cell Biology, 6, 21-30 (2004).

Kodama A, Karakesisoglou I, Wong E, Polak L and Fuchs E. "ACF7: an essential integrator of microtubule dynamics," Cell 115, 343-354 (2003).

Jamora C, DasGupta, R, Kocieniewski, P and Fuchs, E. Links between signal transduction, transcription and adhesion in epithelial bud development. Nature, 422: 317-322 (2003).

Vaezi A, Bauer C, Vasioukhin V & Fuchs E. Actin cable dynamics & Rho/Rock orchestrate a polarized cytoskeletal architecture in assembling a stratified epithelium Dev Cell 3, 367-381 (2002).

* Information taken from Dr. Elaine Fuchs’ web page at http://www.hhmi.org/research/investigators/fuchs_bio.html