Molecular biology of neural development and regeneration
Anne Calof's research abstract*:
Dr. Calof's laboratory's research efforts are concentrated on understanding the nature and the
targets of the signals that regulate the production of neurons by neuronal progenitor cells,
during development and regeneration of the nervous system. To study these issues, they concentrate
primarily on one system, in which the behavior of neuronal progenitor cells can be observed and
manipulated easily: the olfactory epithelium (OE) of the mouse. They study the molecular regulation
of neurogenesis and neuronal regeneration using a variety of approaches, including tissue culture,
molecular biology, and the generation and analysis of transgenic mice.
Anne Calof's research images*:
Selected Publications*:
Lander, A.D., Kawauchi, S., Lopez-Burke, M., Chua, A., and Calof, A.L. (2005) Towards a mouse
model of Cornelia de Lange Syndrome. Proceedings of the Greenwood Genetic Center 24: 172-173.
Krantz, I.D., McCallum, J., DeScipio, C., Kaur, M., Gillis, L.A., Yaeger, D., Jukofsky, L.,
Wasserman, N., Bottani, A., Morriss, C.A., Nowaczyk, J.M., Toriello, H., Bamshad, M.J., Carey,
J.C., Rappaprot, E., Kawauchi, S., Lander, A.D., Calof, A.L., Li, H.-H., Devoto, M., and
Jackson, L.G. (2005). Mutations in NIPBL, the human homologue of the Drosophila Nipped-B gene,
cause Cornelia de Lange Syndrome. Proceedings of the Greenwood Genetic Center 24: 171-172.
Kawauchi S., Shou, J., Santos R., Hebert J., McConnell S.K., Mason, I., and Calof, A.L. (2005)
Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal
cavity development in the mouse. (In revision for Development).
**Kim, J., Wu, H.-H., Lander, A.D., Lyons, K.M., Matzuk, M. M., and Calof, A.L. (2005).
GDF11 controls the timing of progenitor cell competence in developing retina. Science 308: 1927-1930.
** See additional reports in Science (Vol. 308, p.1838); the Orange County Register (June 24, 2005);
the Santa Barbara News-Press (June 25, 2005); Obesity, Fitness, and Wellness Week (July 16, 2005),
and online at: http://today.uci.edu/news/release_detail.asp?key=1344);
http://www.blindness.org/research.asp?id=253;
Sci. STKE, Vol. 2005, Issue 290, pp. tw236, 28 June 2005 [DOI: 10.1126/stke.2902005tw236]
Beites, C., Kawauchi, S., Crocker, C.E., and Calof, A.L. (2005) Identification and molecular
regulation of neural stem cells in the olfactory epithelium. Experimental Cell Research 306: 309-316.
