Publications

Black A. T., Gray J. P., Shakarjian M. P., Laskin D. L., Heck D. E., and Laskin J. D. Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis, 2007 [e pub ahead of print].

Hofmann P.A., Israel M., Koseki Y., Laskin J. D., Gray J. P., Janik A., Sweatman T. W., Lothstein L. N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC-epsilon activation. J Pharmacol Exp Ther 323 (2): 658-664. 2007. [link]

Gray, J. P., Heck, D. E., Mishin, V., Smith, P. J., Hong, J. Y., Thiruchelvam, M., Cory-Slechta, D. A., Laskin, D. L., and Laskin, J. D.  Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:Paraquat Oxidoreductase: Identification of the enzyme as thioredoxin reductase.  J Biol Chem 282 (11): 7939-7949.  2007. [link]

Gray, J. P., Davis, J. W., Gopinathan, L., Leas, T. L., Nugent, C. A., Vanden Heuvel, J. P.  The ribosomal protein L11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor alpha.  Toxicol Sci 89 (2):  535-546.  2006.  [link]

Gray, J. P., Burns, K. A., Leas, T. L., and Vanden Heuvel, J. P.  Regulation of Peroxisome Proliferator-Activated Receptor a by Protein Kinase C.  Biochemistry 44 (30):  10313-10321.  2005.  [link]

Gray, J. P., Leas, T. L. Obert, E., Brown, E., Clark, G. C., and Vanden Heuvel, J. P.  Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake Erie.  Aquat Toxicol 64 (3):  343-358.  2003.  [link]

Tien, E. S., Gray, J. P., Peters, J. M., and Vanden Heuvel, J. P. Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes:  identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes.  Cancer Res 63 (18): 5767-5780.  2003.  [link]

Gray, J. P., C. W. Maddox, P. C. Tobin, J. D. Gummo, and C. W. Pitts. Reservoir competence of Carcinops pumilio for Salmonella enteritidis (Eubacteriales: Enterobacteriaceae). J Med Entomol 36:888-91. 1999. [link]

 

Abstracts

Gray, J. P., R. P. Casillas, C. L. K. Sabourin, M. Shakarjian, N. D. Heindel, D. R. Gerecke, D. E. Heck, D. L. Laskin, and J. D. Laskin.  Role of antioxidant enzymes in regulating wound healing in vesicant-induced skin toxicity.  Presented at HFM-149, a NATO symposium on chemical weapons, October 9-11, 2007. 

Heck, D. E., J. P. Gray, Michael R. Shakarjian, D. R. Gerecke, R. P. Casillas, and J. D. Laskin.  Evaluation of 2-chloroethyl ethyl sulfide (CEES)-mediated tissue injury using the mouse ear vesicant mode.  Presented at the 2007 annual meeting of CounterACT, Washington D.C.

Gray, J. P., C. L. K. Sabourin, J. D. Laskin, and D. L. Laskin.  Lung inflammatory models for the development of countermeasures against sulfur mustard.  Presented at the 2007 annual meeting of CounterACT, Washington D.C.

Gray, J. P., D. L. Laskin, and J. D. Laskin.  Chemical Terrorism:  the lung as a target.  Presented at the 2007 annual meeting of the New Jersey Thoracic Society. 

Gray, J. P., E. Heart, P. J. S. Smith, D. E. Heck, and J. D. Laskin.  Alloxan redox cycling is not required for inhibition of glucose-stimulated oxygen flux in isolated pancreatic beta islets.  Presented at the 2007 annual meeting of the Society of Toxicology in Charlotte, NC. 

Gardner, C. R., J. P. Gray, J. Dubois, J. D. Laskin, and D. L. Laskin.  Role of Caveolin-1 and Endothelial Nitric Oxide Synthase (eNOS) in acetaminophen-induced hepatotoxicity.  Presented at the 2007 annual meeting of the Society of Toxicology in Charlotte, NC. 

Gray, J. P., Y. Liu, J. D. Laskin, D. E. Heck, V. Badmaev, and M. T. Huang.  Effects of b-boswellic acids on 12-O-tetradecanoylphorbol-13 acetate-induced inflammation, arachidonic acid metabolism, and expression of antioxidant enzyme genes in mouse ears.  Paper presented at the 2007 annual meeting of the American Association for Cancer Research, Los Angeles, CA. 

Gray, J. P., V. M. Mishin, Y.Wang, D. E. Heck, and J. D. Laskin.  Structurally diverse phytochemicals block xenobiotic-induced oxidative stress in prostate tumor cells by inhibiting flavin-containing NADPH oxidases.  Paper presented at the 2007 annual meeting of the American Association for Cancer Research, Los Angeles, CA. 

Wang, Y., J. P. Gray, V. Mishin, D. E. Heck, and J. D. Laskin.  Cytochrome P450 reductase is crucial for redox cycling of mitomycin c but does not mediate its cytotoxicity in Chinese hamster ovary cells.  Paper presented at the 2007 annual meeting of the American Association for Cancer Research, Los Angeles, CA. 

Gray, J. P., Y. Liu, J. D. Laskin, D. E. Heck, C. T.  Ho, and M. T. Huang.  Inhibitory effects of (-)-epigallocatechin gallate, (-)-theaflavins and caffeine on 12-O-tetradecanoylphorbol-13-acetate-induced mouse ear inflammation and expression of inflammatory cytokines.  Paper presented at the 2006 annual meeting of the American Association for Cancer Research, Washington, D. C. 

Gray, J. P., V. M. Mishin, P. J. Smith, M. Thiruchelvam, D. Cory-Slechta, D. E. Heck, and J. D. Laskin.  Paraquat stimulates cyanide-insensitive respiration and NADPH oxidase activity in murine lung epithelial cells.Paper presented at the 2006 Society of Toxicology meeting in San Diego, CA.  

Connor, A., N. Pierre, J. D. Laskin, J. P. Gray, and D. L. Laskin.  2006.  Hypoxia-induced oxidative stress responses in macrophages and epithelial cells.  Paper presented at the 2006 Society of Toxicology meeting in San Diego, CA.  

Gardner, C. R., J. P. Gray, J. M. Dubois, J. D. Laskin, and D. L. Laskin.  2006.  Reduced hepatotoxicity of acetaminophen in Caveolin-1 (Cav-1) knockout mice is associated with increased tissue repair.  Paper presented at the 2006 Society of Toxicology meeting in San Diego, CA. 

Laskin, J. D., J. P. Gray, V. Mishin, D. L. Laskin, and D. E. Heck.  2006.  Role of redox cycling in chemical-induced lung toxicity.  Paper read at the 2006 International Conference on Nanotoxicology:  Biomedical Aspects meeting in Miami, FL. 

Gray, J. P., V. M. Mishin, P. J. Smith, D. E. Heck, and J. D. Laskin.  2005.  Adriamycin increases cyanide-insensitive respiration in tumor cells via activation of NADPH oxidase.  Paper presented at the 2005 Molecular Targets and Cancer Therapeutics (AACR) Meeting, Philadelphia, PA. 

Gray, J. P., V. Mishin, A. M. Vetrano, J. D. Laskin, and D. E. Heck.  2005.  Hydroxyl radical formation and DNA damage induced by UVB light in the presence of transition metals is independent of endogenous photosensitizers.  Paper presented at the 2005 Annual Meeting of the American Association for Cancer Research, Anaheim, CA.

Gray, J. P., V. Mishin, D. E. Heck, and J. D. Laskin.  2005.  Dietary tannic acid stimulates production of reactive oxygen intermediates and growth factor and inflammatory gene expression in human colon tumor cells.  Paper presented at the 2005 Annual Meeting of the American Association for Cancer Research, Anaheim, CA. 

Mishin, V., J. P. Gray, D. E. Heck, and J. D. Laskin. 2005.   Cytochrome P450 reductases mediates enhanced hydroxyl radical formation and DNA damage by redox active chemicals in the presence of transition metals.  Paper presented at the 2005 Annual Meeting of the American Association for Cancer Research, Anaheim, CA. 

Gray, J. P., V. Mishin, D. E. Heck, and J. D. Laskin.  2005.  Tannic acid is a prooxidant and induces cyclooxygenase-2 in human colon cells.  Paper presented at the 44th Annual Meeting of the Society of Toxicology, 2005, at New Orleans, LA. 

Gopinathan, L., J. P. Gray, and J. P Vanden Heuvel.  2005.  Peroxisome Proliferator-Activated Receptor Alpha- and p53-responsive gene regulation by ribosomal protein L11.  Paper presented at the 44th Annual Meeting of the Society of Toxicology, 2005, at New Orleans, LA. 

Mukhopadhyay, R., J. P. Gray, D. E. Heck, A. Black, V. Mishin, M. Thiruchelvam, D. A. Cory-Slechta, J. D. Laskin.  2005.  Induction of Inflammatory Mediators and Antioxidants Following Exposure of Macrophages to Paraquat.  Paper presented at the 44th Annual Meeting of the Society of Toxicology, 2005, at New Orleans, LA. 

Laumbach, R. J., J. P. Gray, H. M. Kipen, J. D. Laskin, and D. L. Laskin.  2004.  Oxidative Stress and Pro-inflammatory Responses to Diesel Exhaust Particles in Human Nasal Epithelium.  2005.  Paper read at the 100th Annual Meeting of the American Thoracic Society, 2004, at Orlando, FL. 

Gray, J. P., Laskin, J. D., Osbourn, D., Smith, P. J., and Heck, D. E.  2005.  Nitric oxide mediates mitochondrial dysfunction in neuroendocrine toxicity.  Paper presented at UMDNJ Research Day, 2005, at New Brunswick, NJ. 

Gray, J. P., and J. P. Vanden Heuvel.  2003. PPARa-dependent regulation of tumor suppressors p19 and c-abl by peroxisome proliferators and phorbol esters.  Paper read at 42nd Annual Meeting of the Society of Toxicology, 2003, at Salt Lake City, UT. 

Gray, J. P., E. S. Tien, J. M. Peters, and J. P. Vanden Heuvel.  2002.  Generation of temperature-sensitive liver cell lines from C57BL6 mice.  Paper read at 41st Annual Meeting of the Society of Toxicology, 2002, at Nashville, TN. 

Gray, J. P., and J. P. Vanden Heuvel. 2001. Peroxisome Proliferator-Activated Receptor alpha is regulated by Protein Kinase C. Paper read at 40th Annual Meeting of the Society of Toxicology, at San Francisco, CA. 

Gray, J. P., and J. P. Vanden Heuvel. 2000. Crosstalk between the peroxisome proliferator-activated receptor alpha and protein kinase C signaling pathways. Paper read at 39th Annual Meeting of the Society of Toxicology, 2000, at Philadelphia, PA.