Instructors:

Course Announcements:

Course Material

  1. Recent advances in chiral separation principles in capillary electrophoresis and capillary electrochromatography. Electrophoresis 2004, 23, 3981–3996. [pdf]
  2. Lab-on-a-chip for drug development. Advanced Drug Delivery Reviews 55 (2003) 349–377. [pdf]
  3. Analysis of benidipine enantiomers in human plasma by liquid chromatography–mass spectrometry using a macrocyclic antibiotic (Vancomycin) chiral stationary phase column. Journal of Chromatography B, 814 (2005) 75–81. [pdf]
  4. The use of proteomics for the assessment of clinical samples in research. Clinical Biochemistry 37 (2004) 943– 952. [pdf]
  5. Use of Metabonomics to Identify Impaired Fatty Acid Metabolism as the Mechanism of a Drug-Induced Toxicity. Chem. Res. Toxicol. 2004, 17, 165-173. [pdf]
  6. Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicology Letters 146 (2004) 197–205. [pdf]
  7. Depletion of the high-abundance plasma proteins. Amino Acids (2004) 27: 249–259. [pdf]
  8. Ion activation methods for tandem mass spectrometry. J. Mass Spectrom. 2004; 39: 1091–1112. [pdf]
  9. Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. J. Mass Spectrom. 2004; 39: 845–855. [pdf]
  10. Quantitative determination of a novel dual PPAR alpha/gama agonist using on-line turbulent flow extraction with liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 814 (2005) 29–36. [pdf]
  11. Recent methodological advances in the mass spectrometric analysis of free and protein-associated 3-nitrotyrosine in human plasma. Journal of Chromatography B, 814 (2005) 1–9. [pdf]
  12. Using NMR for ligand discovery and optimization. Current Opinion in Chemical Biology 2004, 8:387–391. [pdf]
  13. Proteomic approaches in the search for disease biomarkers. Journal of Chromatography B, 814 (2005) 11–19. [pdf]
  14. Bioinformatics strategies for proteomic profiling. Clinical Biochemistry 37 (2004) 636– 641. [pdf]
  15. NMR Spectroscopy Tools for Structure-Aided Drug Design. Angew. Chem. Int. Ed. 2004, 43, 290 – 300. [pdf]
  16. Theory and Applications of NMR-Based Screening in Pharmaceutical Research. Chem. Rev. 2004, 104, 3641-3675. [pdf]
  17. FTICR-Mass Spectrometry for High-Resolution Analysis in Combinatorial Chemistry. BIOTECHNOLOGY AND BIOENGINEERING (COMBINATORIAL CHEMISTRY), VOL. 71, NO. 2, 2000/2001, 149-161. [pdf]
  18. Development of a LC-LC-MS complete heart-cut approach for the characterization of pharmaceutical compounds using standard instrumentation. Journal of Pharmaceutical and Biomedical Analysis 31 (2003) 1153-1166. [pdf]
  19. Delineating Novel Metabolic Pathways of DPC 963, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Rats. Characterization of Glutathione Conjugates of Postulated Oxirene and Benzoquinone Imine Intermediates by LC/MS and LC/NMR. Chem. Res. Toxicol. 2002, 15, 388-399. [pdf]
  20. Drug-Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development. Chem. Res. Toxicol. 2004, 17, 3-16. [pdf]
  21. Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry. Chem. Res. Toxicol. 2004, 17, 1356-1361. [pdf]
  22. Strategies for dealing with metabolite elucidation in drug discovery and development. DDT Vol. 9, No. 7 April 2004. [pdf]
  23. Fourier transform infrared evaluation of microscopic scarring in the cardiomyopathic heart: Effect of chronic AT1 suppression. Analytical Biochemistry 316 (2003) 232–242. [pdf]
  24. METABOLIC PROFILES OF CANCER CELLS. Nature Reviews Cancer 2004, 4, 551-561. [pdf]
  25. Proteomic Applications for the Early Detection of Cancer. Nature Reviews Cancer 2003, 3, 267-275. [pdf]
  26. Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. PNAS 2004, 101(26), 9528-9533. [pdf]
  27. Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization. Science 2004, 306, 471-473. [pdf]
  28. Mass Analysis at the Advent of the 21st Century. Chem. Rev. 2001, 101, 571-606. [pdf]
  29. Molecular profiling approaches for identifying novel biomarkers. Expert Opin. Drug Saf. 2004, 3(2), 137-151.[pdf]
  30. Exploratory Clinical Testing of Neuroscience Drugs. Nature Neuroscience Supplement, 2002, 5, 1023-1025. [pdf]
  31. Clinical biomarkers in drug discovery and development. Nature Reviews Drug Discovery, 2003, 2, 566-580. [pdf]
  32. High-Throughput Method for N-Terminal Sequencing of Proteins by MALDI Mass Spectrometry. Anal. Chem. 2005, 77,645-651. [pdf]
  33. Evaluation of the Orthogonal Projection on Latent Structure Model Limitations Caused by Chemical Shift Variability and Improved Visualization of Biomarker Changes in 1H NMR Spectroscopic Metabonomic Studies. Anal. Chem. 2005, 77,517-526. [pdf]
  34. Direct Characterization of Enzyme–Substrate Complexes by Using Electrosonic Spray Ionization Mass Spectrometry. Angew. Chem. Int. Ed. 2005, 44, 913 –916. [pdf]
  35. Critical Review of Development, Validation, and Transfer for High Throughput Bioanalytical LC-MS/MS Methods. Current Pharmaceutical Analysis, 2005, 1, 3-14. [pdf]
  36. Psychoanalytical Electrochemistry: Dopamine and Behavior. Analytical Chemistry, 2003, September, 414-421. [pdf]
  37. Chiral Analysis by MS: A new quantitative method that is simple and rapid and uses very little sample. Analytical Chemistry, 2003, January, 25-31. [pdf]
  38. Clinical Proteomics: Are We There Yet? Analytical Chemistry, 2003, November, 472-476. [pdf]
  39. Electron ionization for LC-MS. Analytical Chemistry, 2003, December, 497-503. [pdf]
  40. SELDI-TOF MS for Diagnostic Proteomics. Analytical Chemistry, 2003, April, 149-155. [pdf]

Useful Links

  • Literature Search Links
  • Alphabetical List of Chemistry Journals - A list of almost 700 links to chemistry magazines and journals
  • Alphabetical List of Biochemistry, Cell and Molecular Biology Journals
  • Alphabetical List of Journal Abbreviations
  • Cambridge University Chemical Laboratory - Chemistry Journals
  • Electronic Journals Links - Chemistry -Los Alamos National Laboratory
  • New Jour - the Internet list for new journals and newsletters available on the Internet (a list of electronic journals on the Internet, not restricted to just science)
  • Drug discovery & development Glossary
  • Glossary of terms used in medicinal chemistry- IUPAC -Pure Appl. Chem., 70, 1129-1143 (1998)
  • Glossary of terms used in combinatorial chemistry (pdf file) - J.Comb.Chem.2000,2,562-578 or PureAppl.Chem.1999,71(12),2349-2365.
  • Modern Drug Discovery

  • Longqin Hu · Rutgers University School of Pharmacy · Department of Medicinal Chemistry