Physostigmine (Cholinergic)

Electrostatic Potential (red = - ; blue = +)


Updated for Fall 2017



The textbooks we will be using for Fall 2017:

Joseph E. Rice. Organic Chemistry Concepts and Applications for Medicinal Chemistry, Academic Press, 2014, Softcover; ISBN 9780128007396 or eBook; ISBN 9780128008324.

Reference Textbook: David G. Watson. Pharmaceutical Analysis, A Textbook for Pharmacy Students and Pharmaceutical Chemists, 3rd Edition, 2012, Elsevier. ISBN: 0702046213

Students Assisting Students (SAS): for those students who need assistance in Pharmaceutical Chemistry. Please check the

To check your grades during the semester, please go to Sakai.


Longqin Hu, Ph.D. Course Coordinator

Joseph E. Rice, Ph.D.

Course Description:  The mission of the Pharmaceutical Chemistry course is to introduce students to the structure, properties, and analysis (both qualitative and quantitative) of pharmaceutical agents and metabolites as well as the fundamental techniques used for near patient testing in clinical laboratories. Topics include some of the basic concepts in medicinal chemistry as well as methods of pharmaceutical and biomedical analysis such as 1) the drug discovery and development process, 2) review of organic functional groups found in drug molecules, 3) drug-target interactions, 4) physicochemical properties related to drug action such as acid-base properties, equilibrium, and stereochemistry, 5) Chemistry of OTC inorganic drugs, 6) Effect of chemical structure on the metabolism of drug molecules, 7) Fundamentals of neurochemistry, 8) Chromatographic analysis of pharmaceutical agents, metabolites, and clinical samples, 9) Methods for identification of pharmaceutical agents and metabolites, and 10) Spectral techniques used in quantitative analysis of clinical samples.

Lecture Schedule for Fall 2017 (PDF File)

Course Policy for Fall 2017 (PDF file)