Representative Publications

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  1. Mansooreh Jaberi-Pour, Simon Vass, Christopher P. Guise, Jane I. Grove, Richard Knox, Longqin Hu, Eva I. Hyde and Peter F. Searle* Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations. Biochem. Pharmacol. 2009, in press. SummaryPlus | Full Text + Links | PDF
  2. Xinghua Wu, Yu Chen, and Longqin Hu* An improved practical synthesis of protected <alpha>-amino selenocarboxylates and its application to the synthesis of N-(<alpha>-aminoacyl)sulfonamides. Tetrahedron Lett. 2009, 50(40), 5585-5588. SummaryPlus | Full Text + Links | PDF
  3. Auemduan Prawan, Constance Lay Lay Saw, Tin Oo Khor, Young-Sam Keum, Siwang Yu, Longqin Hu and Ah-Ng Tony Kong* Anti-NF-KB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling. Chem. Biol. Interact. 2009, 179(2-3), 202-211. SummaryPlus | Full Text + Links | PDF
  4. Yongying Jiang, Robert S. DiPaola, and Longqin Hu* Synthesis and stereochemical preference of peptide 4 aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA). Bioorg. Med. Chem. Lett. 2009, 19(9), 2587-2590. SummaryPlus | Full Text + Links | PDF
  5. Yiyu Ge, Xinhua Wu, Dazhi Zhang, and Longqin Hu* 3-Aminoxypropionate-based linker system for cyclization activation in prodrug design. Bioorg. Med. Chem. Lett. 2009, 19(3), 941-944.SummaryPlus | Full Text + Links | PDF
  6. Yu Chen and Longqin Hu* Design of anticancer prodrugs for reductive activation. Med. Res. Rev. 2009, 29(1), 29-64. Abstract | Full Text: PDF
  7. Yongying Jiang and Longqin Hu* N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard. Bioorg. Med. Chem. Lett. 2008, 18(14), 4059-4063.. SummaryPlus | Full Text + Links | PDF
  8. Auemduan Prawan, Young-Sam Keum, Tin Oo Khor, Siwang Yu, Sujit Nair, Wenge Li, Longqin Hu, and Ah-Ng Tony Kong* Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression. Pharm. Res. 2008, 25(4), 836-844. [Abstract] [Full Text] [PDF]
  9. Young-Sam Keum, Peter Pil-Jae Chang, Ki Han Kwon, Xiaoling Yuan, Wenge Li, Longqin Hu, and Ah-Ng Tony Kong* 3-Morpholinopropyl isothiocyanate (3MP-ITC) is a novel synthetic isothiocyanate that strongly induces the antioxidant response element (ARE)-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis 2008, 29(3), 594-599. [Abstract] [Full Text] [PDF]
  10. Yongying Jiang, Zhoupeng Zhang, Robert S. DiPaola, and Longqin Hu* Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides. Tetrahedron 2007, 63(43), 10637-10645. SummaryPlus | Full Text + Links | PDF
  11. Yiyu Ge and Longqin Hu* Microwave-assisted deformylation of N-aryl formamide by KF on basic Al2O3. Tetrahedron Lett. 2007, 48(26), 4585-4588. SummaryPlus | Full Text + Links | PDF
  12. Kumar B. Pabbisetty, Xin Yue, Chen Li, Juha-Pekka Himanen, Renping Zhou, Dimitar B. Nikolov, and Longqin Hu* Kinetic analysis of binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay. Protein Sci. 2007, 16(3), 355-361. Abstract | Full: HTML/PDF
  13. Xinghua Wu and Longqin Hu* Efficient amidation from carboxylic acids and azides via selenatriazoline: application to the coupling of amino acids and peptides with azides. J. Org. Chem. 2007, 72(3), 765-774. Abstract | Full: HTML / PDF | Supporting Info
  14. Yongying Jiang and Longqin Hu* Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage. Bioorg. Med. Chem. Lett. 2007, 17(2), 517-521. SummaryPlus | Full Text + Links | PDF
  15. Yongying Jiang, Jiye Han, Chengzhi Yu, Simon O. Vass, Peter F. Searle, Patrick Browne, Richard J. Knox, and Longqin Hu* Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzyl phosphoramide mustards for E. coli nitroreductase activation. J. Med. Chem. 2006, 49(14), 4333-4343. Abstract | Full: HTML / PDF | Supporting Info
  16. Prathima Surabhi, Xinghua Wu, and Longqin Hu* Improved solubility and stability of trialkylammonium selenocarboxylate in organic solvents for efficient amidation with azides. Tetrahedron Lett. 2006, 47(27), 4609-4613. SummaryPlus | Full Text + Links | PDF
  17. Raghavendra S. Navath, Kumar B. Pabbisetty, and Longqin Hu* Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth (III) trichloride. Tetrahedron Lett. 2006, 47(3), 389-393. SummaryPlus | Full Text + Links | PDF
  18. Xinghua Wu and Longqin Hu* Amide bond formation from selenocarboxylates and aromatic azides. Tetrahedron Lett. 2005, 46(28), 8401-8405.SummaryPlus | Full Text + Links | PDF
  19. Longqin Hu* Prodrug approaches to drug delivery. in Drug Delivery: Principles and Applications, B. Wang, T. Siahaan, and R. Soltero, Eds; Wiley & Sons: New York, 2005; pp 125-165.
  20. Peter F Searle,* Ming-Jen Chen, Longqin Hu, Paul R Race, Andrew L Lovering, Jane I Grove, Chris Guise, Mansooreh Jaberipour, Nicholas D James, Vivien Mautner, Lawrence S Young, David J Kerr, Andrew Mountain, Scott A White, and Eva I Hyde Nitroreductase: a prodrug-activating enzyme for gene therapy. Clin. Exp. Pharmacol. Physiol. 2004, 31(11), 811-816. Abstract Full: HTML / PDF
  21. Longqin Hu* Prodrugs: Effective Solutions for Solubility, Permeability, and Targeting Challenges, June 28-29, 2004, Philadelphia, PA, USA, IDrugs 2004, 7(8), 736-742. [Journal] [PDF] [PubMed]
  22. Longqin Hu* The prodrug approach to better targeting. Current Drug Discovery 2004, 4(8), 28-32. [Journal] [PDF]
  23. Longqin Hu,* Chengzhi Yu, Yongying Jiang, Jiye Han, Zhuorong Li, Patrick Browne, Paul R. Race, Richard J. Knox, Peter F. Searle, and Eva I. Hyde Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy. J. Med. Chem. 2003, 46(23), 4818 - 4821. Abstract | Full: HTML / PDF | Supporting Info
  24. Zhuorong Li, Jiye Han, Yongying Jiang, Patrick Browne, Richard J. Knox, and Longqin Hu* Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture. Bioorg. Med. Chem. 2003, 11(19), 4171-4178. SummaryPlus | Full Text + Links | PDF
  25. Bin Liu and Longqin Hu* 5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation. Bioorg. Med. Chem. 2003, 11(18), 3889-3899. SummaryPlus | Full Text + Links | PDF
  26. Jun Zhao, Vatee Pattaropong, Yongying Jiang, and Longqin Hu* Facile synthesis and cleavage of imidazolidines in a novel protection strategy for the preparation of peptides containing a reduced amide bioisostere. Tetrahedron Lett. 2003, 44(2), 229-232. SummaryPlus | Full Text + Links | PDF
  27. Yongying Jiang, Jun Zhao, and Longqin Hu* 2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines. Tetrahedron Lett. 2002, 43(26), 4589-4592. SummaryPlus | Full Text + Links | PDF
  28. Chengzhi Yu and Longqin Hu* Successful Baylis-Hillman Reaction of Acrylamide with Aromatic Aldehydes. J. Org. Chem. 2002, 67(1), 219-223. Abstract | Full: HTML / PDF | Supporting Info
  29. Chengzhi Yu, Bin Liu, and Longqin Hu* Efficient Baylis-Hillman reaction using stoichiometric base catalyst and an aqueous medium. J. Org. Chem. 2001, 66(16), 5413-5418. Abstract | Full: HTML / PDF | Supporting Info
  30. Chengzhi Yu and Longqin Hu* A facile synthesis of cyclic enecarbamates using Dess-Martin periodinane. Tetrahedron Lett. 2001, 42(31), 5167-5170. SummaryPlus | Full Text + Links | Journal Format-PDF
  31. Chengzhi Yu, Bin Liu and Longqin Hu* Samarium(0) and 1,1'-dioctyl-4,4'-bipyridinium dibromide: a novel electron-transfer system for the chemoselective reduction of aromatic nitro groups. J. Org. Chem. 2001, 66(3), 919-924. Abstract | Full: HTML / PDF | Supporting Info
  32. Chengzhi Yu, Yongying Jiang, Bin Liu and Longqin Hu* A facile synthesis of 2-oxazolidinones via Hofmann rearrangement medicated by bis(trifluoroacetoxy)iodobenzene. Tetrahedron Lett. 2001, 42(8), 1449-1452. SummaryPlus | Full Text + Links | Journal Format-PDF
  33. Chengzhi Yu, Bin Liu and Longqin Hu* A simple one-pot procedure for the conversion of alcohols to azides using phosphate activation. Org. Lett. 2000, 2(13), 1959-1961. Abstract | Full Text - HTML | Full Article - PDF
  34. Chengzhi Yu, Bin Liu and Longqin Hu* A convenient biphasic process for the monosilylation of symmetrical 1,n-primary diols. Tetrahedron Lett. 2000, 41(22), 4281-4285. SummaryPlus | Full Text + Links | Journal Format-PDF
  35. Longqin Hu*, Bin Liu and Douglas R. Hacking 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductive activated prodrug of FUDR: synthesis, stability, and reductive activation. Bioorg. Med. Chem. Lett. 2000, 10(8), 797-800. SummaryPlus | Full Text + Links | Journal Format-PDF
  36. Chengzhi Yu, Bin Liu and Longqin Hu* A modified procedure for the deprotection of methoxymethyl ether. Tetrahedron Lett. 2000, 41(6), 819-822. SummaryPlus | Full Text + Links | Journal Format-PDF
  37. Longqin Hu and Roberta F. Colman* Resonance Energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at Cys17 and Cys111. Biochemistry 1997, 36 (7),1635-1645. Abstract | Full: HTML / PDF
  38. Longqin Hu, Barbara L. Borleske and Roberta F. Colman* Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane. Protein Science 1997, 6 (1), 43-52. [Abstract] [Full Text - HTML]
  39. Longqin Hu and Roberta F. Colman* Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3. J. Biol. Chem. 1995, 270 (37), 21875-21883. [Abstract] [Full Text] [PDF]
  40. Longqin Hu, Preeti Balse and Michael B. Doughty* Neuropeptide Y N-terminal deletion fragments: Correlation between solution structure and receptor binding activity at Y1 receptors in rat brain cortex. J. Med. Chem. 1994, 37 (21), 3622-3629. Abstract | Full Text - PDF
  41. Longqin Hu and Michael B. Doughty* Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label. J. Protein Chem. 1994, 13 (1), 135-140. Abstract | Full Text - PDF
  42. Michael B. Doughty* and Longqin Hu The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment. Biopolymers 1993, 33 (8), 1195-1206. Abstract | Full Text - PDF
  43. Michael B. Doughty,* Ke Li, Longqin Hu, Shao Song Chu and Richard Tessel Benextramine neuropeptide Y (NPY) binding site interactions: characterization of NPY binding site heterogeneity in rat brain. Neuropeptides 1992, 23 (3), 169-180. [Abstract]
  44. Longqin Hu and Deyu Xu* HPLC separation and characterization of chlorin derivatives with intact ring V from acid degradation products of silkworm excrement crude chlorophyll mixture. Biomed. Chromatogr. (London) 1989, 3(2), 72-74. Abstract | Full Text - PDF

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Longqin Hu · Rutgers University School of Pharmacy · Department of Medicinal Chemistry