1. Sadagopan Magesh, Yu Chen, and Longqin Hu* Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med. Res. Rev. 2012, in press.
2. Daigo Inoyama, Yu Chen, Xinyi Huang, Lesa J. Beamer, Ah-Ng Tony Kong, and Longqin Hu* Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction. J. Biomol. Screen. 2012, in press. Abstract | Full Text + Links | PDF
3. Yu Chen, Daigo Inoyama, Ah-Ng Kong, Lesa J. Beamer, and Longqin Hu* Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using Surface Plasmon Resonance. Chem. Biol. Drug Des. 2011, 78(6), 1014-1021. Abstract | Full Text + Links | PDF
4. Yanhui Yang, Herve Aloysius, Daigo Inoyama, Yu Chen, and Longqin Hu* Enzyme-mediated hydrolytic activation of prodrugs. Acta Pharmaceutica Sinica B 2011, 1(3), 143-159. Abstract | Full Text + Links | PDF
5. Xinghua Wu, Yu Chen, Herve Aloysius, and Longqin Hu* A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: important synthons for the synthesis of chromogenic/fluorogenic protease substrates. Beilstein J. Org. Chem. 2011, 7, 1030-1035. HTML | PDF | Album | Supporting Information
6. Longqin Hu,* Xinghua Wu, Jiye Han, Lin Chen, Simon O. Vass, Patrick Browne, Belinda S. Hall, Christopher Bot, Vithurshaa Gobalakrishnapilla, Peter F. Searle, Richard J. Knox, and Shane R. Wilkinson Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. Bioorg. Med. Chem. Lett. 2011, 21(13), 3986-3991. SummaryPlus | Full Text + Links | PDF
7. Yang Zhao, Mao-Jung Lee, Connie Cheung, Ji-Hyeung Ju, Yu-Kuo Chen, Ba Liu, Longqin Hu, and Chung S. Yang* Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans. J. Agric. Food Chem. 2010, 58(8), 4844–4852. Abstract | Full Text + Links | PDF
8. Belinda S. Hall, Xinghua Wu, Longqin Hu, and Shane R. Wilkinson* Exploiting the drug-activating properties of a novel trypanosomal nitroreductase. Antimicrob. Agents Chemother. 2010, 54(3), 1193-1199. Abstract | Full Text + Links | PDF
9. Mansooreh Jaberi-Pour, Simon Vass, Christopher P. Guise, Jane I. Grove, Richard Knox, Longqin Hu, Eva I. Hyde and Peter F. Searle* Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations. Biochem. Pharmacol. 2010, 79(2), 102-111. Abstract | Full Text + Links | PDF
10. Xinghua Wu, Yu Chen, and Longqin Hu* An improved practical synthesis of protected <alpha>-amino selenocarboxylates and its application to the synthesis of N-(<alpha>-aminoacyl)sulfonamides. Tetrahedron Lett. 2009, 50(40), 5585-5588. SummaryPlus | Full Text + Links | PDF
11. Auemduan Prawan, Constance Lay Lay Saw, Tin Oo Khor, Young-Sam Keum, Siwang Yu, Longqin Hu and Ah-Ng Tony Kong* Anti-NF-KB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling. Chem. Biol. Interact. 2009, 179(2-3), 202-211. SummaryPlus | Full Text + Links | PDF
12. Yongying Jiang, Robert S. DiPaola, and Longqin Hu* Synthesis and stereochemical preference of peptide 4 aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA). Bioorg. Med. Chem. Lett. 2009, 19(9), 2587-2590. SummaryPlus | Full Text + Links | PDF
13. Yiyu Ge, Xinhua Wu, Dazhi Zhang, and Longqin Hu* 3-Aminoxypropionate-based linker system for cyclization activation in prodrug design. Bioorg. Med. Chem. Lett. 2009, 19(3), 941-944.SummaryPlus | Full Text + Links | PDF
14. Yu Chen and Longqin Hu* Design of anticancer prodrugs for reductive activation. Med. Res. Rev. 2009, 29(1), 29-64. Abstract | Full Text: PDF
15. Yongying Jiang and Longqin Hu* N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard. Bioorg. Med. Chem. Lett. 2008, 18(14), 4059-4063.. SummaryPlus | Full Text + Links | PDF
16. Auemduan Prawan, Young-Sam Keum, Tin Oo Khor, Siwang Yu, Sujit Nair, Wenge Li, Longqin Hu, and Ah-Ng Tony Kong* Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression. Pharm. Res. 2008, 25(4), 836-844. [Abstract] [Full Text] [PDF]
17. Young-Sam Keum, Peter Pil-Jae Chang, Ki Han Kwon, Xiaoling Yuan, Wenge Li, Longqin Hu, and Ah-Ng Tony Kong* 3-Morpholinopropyl isothiocyanate (3MP-ITC) is a novel synthetic isothiocyanate that strongly induces the antioxidant response element (ARE)-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis 2008, 29(3), 594-599. [Abstract] [Full Text] [PDF]
18. Yongying Jiang, Zhoupeng Zhang, Robert S. DiPaola, and Longqin Hu* Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides. Tetrahedron 2007, 63(43), 10637-10645. SummaryPlus | Full Text + Links | PDF
19. Yiyu Ge and Longqin Hu* Microwave-assisted deformylation of N-aryl formamide by KF on basic Al2O3. Tetrahedron Lett. 2007, 48(26), 4585-4588. SummaryPlus | Full Text + Links | PDF
20. Kumar B. Pabbisetty, Xin Yue, Chen Li, Juha-Pekka Himanen, Renping Zhou, Dimitar B. Nikolov, and Longqin Hu* Kinetic analysis of binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay. Protein Sci. 2007, 16(3), 355-361. Abstract | Full: HTML/PDF
21. Xinghua Wu and Longqin Hu* Efficient amidation from carboxylic acids and azides via selenatriazoline: application to the coupling of amino acids and peptides with azides. J. Org. Chem. 2007, 72(3), 765-774. Abstract | Full: HTML / PDF | Supporting Info
22. Yongying Jiang and Longqin Hu* Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage. Bioorg. Med. Chem. Lett. 2007, 17(2), 517-521. SummaryPlus | Full Text + Links | PDF
23. Yongying Jiang, Jiye Han, Chengzhi Yu, Simon O. Vass, Peter F. Searle, Patrick Browne, Richard J. Knox, and Longqin Hu* Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzyl phosphoramide mustards for E. coli nitroreductase activation. J. Med. Chem. 2006, 49(14), 4333-4343. Abstract | Full: HTML / PDF | Supporting Info
24. Prathima Surabhi, Xinghua Wu, and Longqin Hu* Improved solubility and stability of trialkylammonium selenocarboxylate in organic solvents for efficient amidation with azides. Tetrahedron Lett. 2006, 47(27), 4609-4613. SummaryPlus | Full Text + Links | PDF
25. Raghavendra S. Navath, Kumar B. Pabbisetty, and Longqin Hu* Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth (III) trichloride. Tetrahedron Lett. 2006, 47(3), 389-393. SummaryPlus | Full Text + Links | PDF
26. Xinghua Wu and Longqin Hu* Amide bond formation from selenocarboxylates and aromatic azides. Tetrahedron Lett. 2005, 46(28), 8401-8405.SummaryPlus | Full Text + Links | PDF
27. Longqin Hu* Prodrug approaches to drug delivery. in Drug Delivery: Principles and Applications, B. Wang, T. Siahaan, and R. Soltero, Eds; Wiley & Sons: New York, 2005; pp 125-165.
28. Peter F Searle,* Ming-Jen Chen, Longqin Hu, Paul R Race, Andrew L Lovering, Jane I Grove, Chris Guise, Mansooreh Jaberipour, Nicholas D James, Vivien Mautner, Lawrence S Young, David J Kerr, Andrew Mountain, Scott A White, and Eva I Hyde Nitroreductase: a prodrug-activating enzyme for gene therapy. Clin. Exp. Pharmacol. Physiol. 2004, 31(11), 811-816. Abstract Full: HTML / PDF
29. Longqin Hu* Prodrugs: Effective Solutions for Solubility, Permeability, and Targeting Challenges, June 28-29, 2004, Philadelphia, PA, USA, IDrugs 2004, 7(8), 736-742. [Journal] [PDF] [PubMed]
30. Longqin Hu* The prodrug approach to better targeting. Current Drug Discovery 2004, 4(8), 28-32. [Journal] [PDF]
31. Longqin Hu,* Chengzhi Yu, Yongying Jiang, Jiye Han, Zhuorong Li, Patrick Browne, Paul R. Race, Richard J. Knox, Peter F. Searle, and Eva I. Hyde Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy. J. Med. Chem. 2003, 46(23), 4818 - 4821. Abstract | Full: HTML / PDF | Supporting Info
32. Zhuorong Li, Jiye Han, Yongying Jiang, Patrick Browne, Richard J. Knox, and Longqin Hu* Nitrobenzocyclophosphamides as potential prodrugs for bioreductive activation: synthesis, stability, enzymatic reduction, and antiproliferative activity in cell culture. Bioorg. Med. Chem. 2003, 11(19), 4171-4178. SummaryPlus | Full Text + Links | PDF
33. Bin Liu and Longqin Hu* 5'-(2-Nitrophenylalkanoyl)-2'-deoxy-5-fluorouridines as potential prodrugs of FUDR for reductive activation. Bioorg. Med. Chem. 2003, 11(18), 3889-3899. SummaryPlus | Full Text + Links | PDF
34. Jun Zhao, Vatee Pattaropong, Yongying Jiang, and Longqin Hu* Facile synthesis and cleavage of imidazolidines in a novel protection strategy for the preparation of peptides containing a reduced amide bioisostere. Tetrahedron Lett. 2003, 44(2), 229-232. SummaryPlus | Full Text + Links | PDF
35. Yongying Jiang, Jun Zhao, and Longqin Hu* 2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines. Tetrahedron Lett. 2002, 43(26), 4589-4592. SummaryPlus | Full Text + Links | PDF
36. Chengzhi Yu and Longqin Hu* Successful Baylis-Hillman Reaction of Acrylamide with Aromatic Aldehydes. J. Org. Chem. 2002, 67(1), 219-223. Abstract | Full: HTML / PDF | Supporting Info
37. Chengzhi Yu, Bin Liu, and Longqin Hu* Efficient Baylis-Hillman reaction using stoichiometric base catalyst and an aqueous medium. J. Org. Chem. 2001, 66(16), 5413-5418. Abstract | Full: HTML / PDF | Supporting Info
38. Chengzhi Yu and Longqin Hu* A facile synthesis of cyclic enecarbamates using Dess-Martin periodinane. Tetrahedron Lett. 2001, 42(31), 5167-5170. SummaryPlus | Full Text + Links | Journal Format-PDF
39. Chengzhi Yu, Bin Liu and Longqin Hu* Samarium(0) and 1,1'-dioctyl-4,4'-bipyridinium dibromide: a novel electron-transfer system for the chemoselective reduction of aromatic nitro groups. J. Org. Chem. 2001, 66(3), 919-924. Abstract | Full: HTML / PDF | Supporting Info
40. Chengzhi Yu, Yongying Jiang, Bin Liu and Longqin Hu* A facile synthesis of 2-oxazolidinones via Hofmann rearrangement medicated by bis(trifluoroacetoxy)iodobenzene. Tetrahedron Lett. 2001, 42(8), 1449-1452. SummaryPlus | Full Text + Links | Journal Format-PDF
41. Chengzhi Yu, Bin Liu and Longqin Hu* A simple one-pot procedure for the conversion of alcohols to azides using phosphate activation. Org. Lett. 2000, 2(13), 1959-1961. Abstract | Full Text - HTML | Full Article - PDF
42. Chengzhi Yu, Bin Liu and Longqin Hu* A convenient biphasic process for the monosilylation of symmetrical 1,n-primary diols. Tetrahedron Lett. 2000, 41(22), 4281-4285. SummaryPlus | Full Text + Links | Journal Format-PDF
43. Longqin Hu*, Bin Liu and Douglas R. Hacking 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductive activated prodrug of FUDR: synthesis, stability, and reductive activation. Bioorg. Med. Chem. Lett. 2000, 10(8), 797-800. SummaryPlus | Full Text + Links | Journal Format-PDF
44. Chengzhi Yu, Bin Liu and Longqin Hu* A modified procedure for the deprotection of methoxymethyl ether. Tetrahedron Lett. 2000, 41(6), 819-822. SummaryPlus | Full Text + Links | Journal Format-PDF
45. Longqin Hu and Roberta F. Colman* Resonance Energy transfer between sites in rat liver glutathione S-transferase, 1-1, selectively modified at Cys17 and Cys111. Biochemistry 1997, 36 (7),1635-1645. Abstract | Full: HTML / PDF
46. Longqin Hu, Barbara L. Borleske and Roberta F. Colman* Probing the active site of alpha-class rat liver glutathione S-transferases using affinity labeling by monobromobimane. Protein Science 1997, 6 (1), 43-52. [Abstract] [Full Text - HTML]
47. Longqin Hu and Roberta F. Colman* Monobromobimane as an affinity label of the xenobiotic binding site of rat glutathione S-transferase 3-3. J. Biol. Chem. 1995, 270 (37), 21875-21883. [Abstract] [Full Text] [PDF]
48. Longqin Hu, Preeti Balse and Michael B. Doughty* Neuropeptide Y N-terminal deletion fragments: Correlation between solution structure and receptor binding activity at Y1 receptors in rat brain cortex. J. Med. Chem. 1994, 37 (21), 3622-3629. Abstract | Full Text - PDF
49. Longqin Hu and Michael B. Doughty* Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label. J. Protein Chem. 1994, 13 (1), 135-140. Abstract | Full Text - PDF
50. Michael B. Doughty* and Longqin Hu The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment. Biopolymers 1993, 33 (8), 1195-1206. Abstract | Full Text - PDF
51. Michael B. Doughty,* Ke Li, Longqin Hu, Shao Song Chu and Richard Tessel Benextramine neuropeptide Y (NPY) binding site interactions: characterization of NPY binding site heterogeneity in rat brain. Neuropeptides 1992, 23 (3), 169-180. [Abstract]
52. Longqin Hu and Deyu Xu* HPLC separation and characterization of chlorin derivatives with intact ring V from acid degradation products of silkworm excrement crude chlorophyll mixture. Biomed. Chromatogr. (London) 1989, 3(2), 72-74. Abstract | Full Text - PDF
53. Longqin Hu and Deyu Xu* Studies on photochemodiagnostic and photochemotherapeutic agents for human malignancies III: separation and identification of pheophorbides from the acid degradation products of silkworm excrement crude chlorophyll. Zhongguo Yiyao Gongye Zazhi 1988, 19(4), 157-161 (Ch).
54. Jun Liu, Longqin Hu, and Deyu Xu* The sensitizing effect of porphyrin derivatives on the photo oxidation of NADPH in deuterium oxide. Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo) 1988, 9(5), 435-437.
55. Lilin Liu*, Jiqiu Yang, Longqin Hu, Jianguo Lu, Jianhuang Zhao and Yijie Wu Synthesis and antifungal activity of some imidazolyl oxime ether derivatives. J. Med. Coll. PLA 1988, 3(2), 95-99.
56. Lilin Liu*, Jiqiu Yang, Longqin Hu, Jianguo Lu, Jianhuang Zhao and Yijie Wu Synthesis and antifungal activity of imidazolyl oxime ether derivatives. Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo) 1988, 9(2), 100-105 (Ch).
57. Longqin Hu and Deyu Xu* On the chemistry of pheophorbide a: A novel photosensitizer. J. Med. Coll. PLA 1987, 2(2), 162-166.
58. Longqin Hu and Deyu Xu* Pheophorbide a as a novel photosensitizer for the Photodynamic Therapy of Cancer. Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo) 1987, 8(1), 1-6 (Ch).
59. Longqin Hu and Deyu Xu* On the medical applications of chlorophills and derivatives: a review. World Pharmacy - Synthetics, Biochemicals and Pharmaceutics (Guowei Yiyao – Hechengyao, Shenghuayao, Zhiji) 1987, 8(3), 146-153 (Ch).
60. Longqin Hu and Deyu Xu* Studies on pheophorbide a as a novel antitumor photosensitizer. Academic J. Second Military Med. Univ. (Dier Junyi Daxue Xuebo) 1986, 7, 405-409 (Ch).
    

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Longqin Hu · Rutgers University School of Pharmacy · Department of Medicinal Chemistry