RUTGERS,THE
|
Mark O.
West, Ph.D. |
|
Graduate
Program In Behavioral Neuroscience, Department of Psychology Graduate
Program In Neuroscience, UMDNJ/Cell Biology & Neuroscience Degrees: B.S. University of Ph.D. |
email: markwest@rutgers.edu phone 848-445-8886 fax 732-445-2263
Striatal reorganization in parkinsonian model: Video option #1 Video option #2 Press release
Accumbens activation during cue-induced relapse to cocaine seeking: Press release #1 Press release #2
Department
of Psychology Behavioral
Neuroscience Graduate Program UMDNJ
Neuroscience Graduate Program
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NEUROPHYSIOLOGY LABORATORY
Research Interests
This laboratory studies the activity of neurons that receive dopaminergic synaptic input, during behaviors correlated with dopamine transmission. Our long range goal is to better understand the activity of dopamine's target neurons with respect to reward learning and drug abuse. We record the activity of arrays of single neurons in the striatum of awake, unrestrained rats, in the sensorimotor (putamen) and limbic (accumbens) subregions of the striatum. Our present models include
1) intravenous cocaine self-administration: firing patterns of neurons in accumbens, ventral pallidum and dorsolateral striatum in relation to conditioned incentive cues that cause reinstatement of cocaine seeking
2) experience dependent changes in movement-related firing of putamen neurons as a function repeated exposure to cocaine and/or behavioral task
3) ultrasonic vocalizations of rats, coupled to
neural recordings during appetitive or aversive behaviors
IN MEMORIAM: Dr. Volodymyr
Prokopenko
Research
Associate from Bogomoletz Institute for Physiology,
Our dear
colleague died too young of mantle lymphoma in April, 2006.
CURRENT PERSONNEL
Dr.
Anthony Fabbricatore
Research Associate
Neurophysiological
mechanisms of cocaine addiction
Postdoctoral Fellow
Statistical analysis of neurobehavioral data in
models of addiction
Graduate Students:
David Root droot@eden.rutgers.edu
Sisi Ma sisima@eden.rutgers.edu
David Barker djbarker@eden.rutgers.edu
Kevin Coffey mrcoffey@eden.rutgers.edu
==========================
Undergraduate researchers:
Shaili Jha
Trishala Parthasarathi
Steven Simmons
Danielle Bercovicz
Laura Megehee
Lisa Servilio
Carla Ralston
Brendan Striano
Kyle Ditmars
Lindsey Crocker
===================================
Previous graduate students:
Dr. Regina M. Carelli
Ph.D. 1991 (Honorable Mention: Lindsley Prize,
Soc. for Neuroscience)
Professor
Department of Psychology
Dr. Martin M. Wolske
Ph.D. 1993; M.S. 1990
Manager of Systems Services
Prairienet Community Information Network
Dr. Cathy Pederson
Ph.D. 1996
Associate Professor
Department of Biology
Dr. Jeiwon Cho
Ph.D. 1996; M.S. 1993
Professor and laboratory head
Korean Institute of Science and Technology
Seoul, South
Dr. Anthony Uzwiak Ph.D. 1996
Adjunct Professor
Department of Cell Biology & Neuroscience
Rutgers University
Piscataway, NJ
Taliah Mittler Ph.D. 2008; M.S. 1994
Research Associate
Reno, Nevada
Francis Guyette,
M.D. M.S. 1997
Kathryn Muccino
M.S. 1999
Acquisitions Editor
Gordon Breach Publishing
Dr. Anthony Fabbricatore Ph.D. 2000
Research Associate
Department of Psychology
New Brunswick, NJ
Dr. Dawn C.
Duke M.S. 2000
Department of Neuropathology
Dr. Udi Ghitza
Ph.D. 2004
National Institute on Drug Abuse
Health Science Administrator, Center for Clinical Trials Network
Anthony Pawlak M.S. 2004
Postdoctoral Fellow
Dr. Chengke Tang M.S. 2004
Research Associate
Yun Zhu
M.S. 2006
Research Biologist
Merck Pharmaceuticals
West Point, PA
Sisi Ma M.S. 2011
David Barker M.S.
2011
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PUBLICATIONS
Schubert, P., Lee, K., West, M., Deadwyler, S. and Lynch, G. (1976). Stimulation dependent release of [3-H]-adenosine from central axon terminals to target neurons. Nature (Lond) 260: 541-542.
Deadwyler, S., West, M. and Lynch, G. (1979a). Synaptically identified hippocampal slow potentials during behavior. Brain Res. 161: 211-225.
Deadwyler, S., West, M. and Lynch, G. (1979b). Activity of dentate granule cells during learning: differentiation of perforant path input. Brain Res. 169: 29-43.
Deadwyler, S., Biela, J., Rose, G., West, M. and Lynch, G. (1980). An improved miniature microdrive for recording from freely moving rats. Electroenceph. Clin. Neurophys. 47:752-754.
West, M.O. and Deadwyler, S.A. (1980). Circadian modulation of granule cell response to perforant path synaptic input in the rat. Neuroscience 5: 1597-1602.
West, M.O., Christian, E., Robinson, J.H. and Deadwyler, S.A. (1981). Dentate granule cell discharge during conditioning: Relation to movement and theta rhythm. Exp. Brain Res. 44: 287-297.
West, M.O., Christian, E.P., Robinson, J.J. and Deadwyler, S.A. (1982). Evoked potentials in the dentate gyrus reflect the retention of past sensory events. Neurosci. Lett. 28: 319-324.
West, M.O. and Woodward, D.J. (1984). A technique for microiontophoretic study of single neurons in the freely moving rat. J. Neurosci. Methods, 11: 179-186.
Christian,
E., West, M. and Deadwyler, S. (1986). Opiates and opioid
peptides modify sensory evoked potentials and synaptic excitability in the rat
dentate gyrus. Neuropharmacol.,
24: 607-615.
West,
M.O., Chapin, J.K. and Woodward, D.J. (1986) A computer-based system for
control and analysis of iontophoretic studies of
single neurons in behaving animals. In: Modern Methods in
Pharmacology: Electrophysiological Techniques, (ed.) H.M. Geller,
West,
M.O., Michael, A.J., Knowles, S.E., Chapin, J.K. and Woodward, D.J.
(1987). Striatal unit activity and the linkage between sensory and motor
events. In: Basal Ganglia and Behavior: Sensory Aspects of
Motor Functioning, (eds.) J.S. Schneider and T.I. Lidsky,
Foster,
T.C., Hampson, R.E., West, M.O., and
J. Neurosci. 8: 3869-3878.
West, M.O., Carelli, R.M., Cohen, S.M., Gardner, J.P., Pomerantz, M., Chapin, J.K. and Woodward, D.J. (1990). A region in the dorsolateral striatum of the rat exhibiting single unit correlations with specific locomotor limb movements. J. Neurophysiol. 64: 690-703. JNphys1990.pdf
Carelli, R.M., and West, M.O. (1991). Representation of the body by single neurons in the dorsolateral striatum of the awake, unrestrained rat. J. Comp. Neurol. 309: 231-249. J Comp Neurol.pdf
West, M.O., Peoples, L.L., Wolske, M. and Dworkin, S.I. (1992) Psychomotor stimulant effects on single neurons in awake, behaving rats. In: Brown, R. and Frascella, J. (eds.) The Neurobiology of Brain-Behavior Interactions in Drug Abuse. Nat'l Institute on Drug Abuse Research Monograph #124, Washington, DC: Supt. of Docs., U.S. Govt. Printing Off., 57-71.
Wolske, M., Rompre, P-P, Wise, R., and West, M.O. (1993) Activation of single neurons in the rat nucleus accumbens during self-stimulation of the ventral tegmental area. J. Neurosci. 13: 1-12. Abstract
Mittler, T. Cho, J., Peoples, L.L. and West, M.O. (1994) Representation of the body in the lateral striatum of freely moving rats: single neurons related to licking. Exp. Brain Res. 98: 163-167.
Peoples, L.L. and West, M.O. (1996) Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration. J. Neurosci. 16: 3459-3473. View article
West, M.O., Peoples, L.L., Michael, A.J., Chapin, J.K. and Woodward, D.J. (1997) Low-dose amphetamine elevates movement-related firing of rat striatal neurons. Brain Res. 745: 331-335. View article
Carelli, R.M., Wolske, M. and West, M.O. (1997) Loss of lever press-related firing of rat striatal forelimb neurons after repeated sessions in a lever pressing task. J. Neurosci. 17:1804-1814. View article
Cho, J. and West, M.O. (1997) Distributions of single neurons related to body parts in the lateral striatum of the rat. Brain Res. 756: 241-246. View article
Peoples, L.L., Uzwiak, A.J., Gee, F. and West, M.O. (1997) Operant behavior is necessary and sufficient for phasic firing of rat accumbens neurons during sessions of intravenous cocaine infusions. Brain Res. 757: 280-284. View article
Pederson, C.L., Wolske, M., Peoples, L.L, and West, M.O. (1997) Firing rate dependent effect of cocaine on firing of single neurons in the rat lateral striatum, Brain Res. 760: 261-265. View article
Uzwiak, A.J., Guyette, F.X., West, M.O. and Peoples, L.L. (1997) Neurons in accumbens subterritories of the rat: Phasic firing time-locked within seconds of intravenous cocaine self-infusion. Brain Res. 767: 363-369. View article
Prokopenko, V.F., Shevko, G.N., Voloshin, M.Ya., and West, M.O. (1997) A removable peripheral device for intracerebral microinjection in freely moving rats. Brain Res. Protocols 2: 31-34.
Peoples, L.L., Uzwiak, A.J., Guyette, F.X., and West, M.O. (1998) Tonic inhibition of single nucleus accumbens neurons in the rat: a predominant but not exclusive firing pattern induced by cocaine self-administration sessions. Neurosci. 86: 13-22. View article
Peoples, L.L., Gee, F., Bibi, R., and West, M.O. (1998) Phasic firing time-locked to cocaine self-infusion and locomotion: dissociable firing patterns of single nucleus accumbens neurons in the rat. J. Neurosci. 18: 7588-7598. View article
West, M.O. (1998) Anesthetics eliminate somatosensory-evoked discharges of neurons in the somatotopically organized sensorimotor striatum of the rat. J. Neurosci. 18: 9055-9068. View article
Peoples, L.L., Uzwiak, A.J., Gee, F., and West, M.O. (1999) Tonic firing of rat nucleus accumbens neurons: changes during the first two weeks of daily cocaine self-administration sessions. Brain Res. 822:231-236. View article
Peoples
LL, Uzwiak AJ, Gee F, Fabbricatore
AT, Muccino KJ, Mohta BD,
Cho, J., Manzino, L., Sonsalla, P.K. Duke, D. and West, M.O. (2002) Dopamine depletion causes fragmented clustering of neurons in the sensorimotor striatum: evidence of lasting reorganization of corticostriatal input J. Comp. Neurol. 452:24-37. View article
Ghitza U, Fabbricatore AT, Prokopenko VF, Pawlak A,
J. Neurosci. 23: 7239-7245. View article
Ghitza U, Fabbricatore AT, Prokopenko VF,
Prokopenko VF, Pawlak A,
Ghitza UE, Prokopenko VF,
Tang C,
Pawlak AP, Prokopenko, VF,
Tang C, Mittler T, Duke DC, Zhu Y, Pawlak AP, West MO. (2008) Dose- and rate-dependent effects of cocaine on striatal firing related to licking. J Pharmacol Exp Ther. 2008 Feb;324(2):701-13. Epub 2007 Nov 8. PubMed PMID: 17991811.
Root DH, Fabbricatore AT, Barker DJ, Ma S, Pawlak AP, West MO. (2009) Evidence for habitual and goal-directed behavior following devaluation of cocaine: a multifaceted interpretation of relapse. PLoS One. 2009 Sep 25;4(9):e7170. PubMed PMID: 19779607; PubMed Central PMCID: PMC2744871.
Fabbricatore A, Ghitza U, Prokopenko VF, West MO.
(2009) Electrophysiological Evidence of Mediolateral
Functional Dichotomy in the Rat Accumbens during Cocaine Self-Administration I:
Tonic Firing Patterns. Eur J Neurosci.
30: 2387–2400. PubMed PMID:
20092580.
Tang CC, Root DH, Duke DC, Zhu Y, Teixeria K, Ma S, Barker DJ, West MO. (2009) Decreased firing of striatal neurons related to licking during acquisition and overtraining of a licking task. J Neurosci. 2009 Nov 4;29(44):13952-61. PubMed PMID: 19890005.
Pawlak, A., Tang, C. Pederson, C.L., Wolske, M. and West, M.O. (2010) Acute effects of cocaine on movement-related firing of dorsolateral striatal neurons depend on baseline firing rate and dose. J Pharmacol Exper Ther. 332:667-683. PubMed PMID: 19906778; PubMed Central PMCID: PMC2812117.
Root DH, Fabbricatore AT, Ma S, Barker DJ, West MO (2010) Rapid phasic activity of ventral pallidal neurons during cocaine self-administration. Synapse. 2010 Mar 17. PubMed PMID: 20340176.
Root DH, Tang CC, Ma S, Pawlak AP, West MO. (2010) Absence of cue-evoked firing in rat dorsolateral striatum neurons. Behav Brain Res. 2010 Jul 29;211(1):23-32. Epub 2010 Mar 6. PubMed PMID: 20211654; PubMed Central PMCID: PMC2864231.
Fabbricatore A, Ghitza U, Prokopenko VF, West MO. (2010) Electrophysiological Evidence of Mediolateral Functional Dichotomy in the Rat Accumbens during Cocaine Self-Administration II: Phasic Firing Patterns. Eur J Neurosci. 31(9):1671-82. PubMed PMID: 20525080.
Barker, David J., Root, David H., Ma, Sisi, Jha, Shaili, Megehee, Laura, West, Mark O. (2010) Dose dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration. Psychopharmacol (Berl). 2010 Sep;211(4):435-42. Epub 2010 Jun 23. PubMed PMID: 20571780.
Root DH, Barker DJ, Ma S, Coffey KR, Fabbricatore AT, West MO. (2011) Evidence for learned skill during cocaine self-administration in rats.
Psychopharmacology (Berl). 2011 Sep;217(1):91-100. Epub 2011 Apr 1.