Title
of course: Biomedical
Transport Phenomena
Course
Location: HILL 116
Course
Index: 07469
Course
Schedule: Wednesdays, 9:50-11:10
AM; Fridays, 1:10-2:30 PM
Instructor:
Professor
Prabhas Moghe, Office: C-230 Engineering
Phone:
445-4951, Email: moghe@rci.rutgers.edu,
Office hours: 2:00 Ð 3:30 PM, Tuesdays, or by Appointment
Prerequisites: Junior standing in Biomedical Engineering; Completion of
Core BME Sophomore Courses
Course
philosophy and description: The transport of mass, energy and
momentum is essential to the function of living systems. This course provides an overview of the scope, aims, and
methods of the subject of transport phenomena, with an emphasis on the
transport of physical and chemical transport processes with applications toward
the development of artificial organs and tissue engineering. The course covers such topics as the
body fluids, capillary solute transport, the physical and flow properties of
blood and a basic review of the relevant momentum balances, tissue oxygen
transport, and mass balances within biomedical devices. The course emphasizes the treatment of
diffusion, and trains students to solve mass transfer problems through the
synthesis of shell balances and obtain mathematical solutions of differential
equations to yield physical descriptions of transport processes. Most examples are analytical in
nature; a few numerical problems
are assigned that utilize the use of MATLAB or equivalent software.
Objectives: To provide students with fundamental principles and
applications of physics and engineering related to the transport of mass. Specifically, students will learn:
á
To
recognize diffusion based problems and formulate appropriate mathematical
constructs for the solution of mass transport problems
á
To
learn the approach for description and quantitation of diffusion through
heterogeneous media such as those prevalent in physiologic systems
á
An
introduction to the field of biorheology, with focus on the transport of blood
and biological fluids.
á
To
integrate the fundamentals of diffusive and membrane transport within
technological problems applied to the fields of tissue engineering,
bioartificial organs, drug delivery, and biotechnology.
Grading
Policy:
Homework (Work individually;
Problems will be graded randomly): 20%
Class Participation (3 Quizzes,
Attendance, Interaction): 30%
One Mid-term Test: 25%
One End-term Test: 25%
Textbooks:
Required:
R.
Fournier, Basic Transport Phenomena in Biomedical Engineering, Taylor and
Francis, 1998
Supplementary
(Not required):
Truskey, G.A., Yuan, F., and Katz, D.F., Transport Phenomena in Biological Systems, Pearson Prentice Hall Bioengineering, 2004
Teaching
Assistant:
Athanas Koynov
TA
Email:
akoynov@soemail.rutgers.edu
TA
Office:
C120 Engineering, Busch Campus
TA Office hours:
Mondays
5-6 PM; Thursdays 2-3 PM (to be
finalized)
Updated:
June 11, 2004
|
Week |
Date |
Topic |
Reading |
|
1 |
Sep 1 W |
Course
Organization and Introduction Ch. 1 Physical
properties of the Body Fluids & Cell Membrane |
1.1 Ð1.7 |
|
|
|
|
|
|
|
Sep 3 F |
Cell Membrane
and Ion Pumps |
1.8-1.12 |
|
|
|
|
|
|
2 |
Sep 8 W |
Ion Transport
contd.; Numerical Examples |
1.13 |
|
|
Sep 10 F |
Ch. 1
contd. Ch. 2, Solute
Transport in Biological Systems - Diffusion |
2.1, 2.5 |
|
|
|
|
|
|
3 |
Sep 15 W |
Diffusion,
Continued; Diffusive transport
through heterogeneous media. |
2.6 |
|
|
Sep 17 F |
Heterogeneous
diffusion, contd; Transport via Membranes |
2.6, 2.8 |
|
|
|
|
|
|
4 |
Sep 22 W |
Solute
transport, continued; Numerical
Examples on diffusion and convection |
2.8-2.12 |
|
|
Sep 24 F |
Solute
transport across the capillaries, contd. Shell balances;
Krogh Tissue Cylinder |
2.12.2 |
|
|
|
|
|
|
5 |
Sep 29 W |
Krogh Tissue
Cylinder, continued. |
2.12.2 |
|
|
Oct 1 F |
Solution
approaches to the Krogh Problem |
2.12.2 |
|
|
|
|
|
|
6 |
Oct 6 W |
Solute
transport in a vascular bedÐ diffusion/convection |
2.13 |
|
|
Oct 8 F |
Numerical
problems on Ch. 2; Momentum
Transport Fundamentals Ch. 3, Physical
and Flow properties of blood. |
3.1 |
|
|
|
|
|
|
7 |
Oct 13 W |
Ch. 3
continued, Review |
3.2-3.3 |
|
|
Oct 15 F |
First Test |
|
|
|
|
|
|
|
8 |
Oct 20 W |
TA
lecture/recitation (IGERT Annual
Symposium on Biointerfaces) |
|
|
|
Oct 22 F |
Ch. 3,
contd. |
3.4-3.8 |
|
|
|
|
|
|
9 |
Oct 27 W |
Ch 3., Marginal
Zone Theory for Blood Flow and Rheology |
3.9-3.12 |
|
|
Oct 29 F |
Ch. 3,
Mechanical Energy Balance Ð BernoulliÕs Equation |
3.13-3.15 |
|
|
|
|
|
|
10 |
Nov. 3 W |
Ch. 4, Oxygen
Transport in Biological Systems |
4.1-4.5 |
|
|
Nov. 5 F |
Ch. 4, Oxygen
Transport, contd. |
4.6-4.7 |
|
|
|
|
|
|
11 |
Nov. 10 W |
Ch. 4, Oxygen
Transport in a Bioartificial Organ |
4.8 |
|
|
Nov. 12 F |
Ch. 6
Extracorporeal Devices - Hemodialysis |
6.6.1 Ð 6.6.4 |
|
|
|
|
|
|
12 |
Nov. 17 W |
Dialysis,
continued; Blood oxygenators |
|
|
|
Nov. 19 F |
Blood
Oxygenator Design |
6.7 |
|
|
|
|
|
|
13 |
Nov. 24 W |
Blood
Oxygenator, continued; Test Review (Fri Schedule) |
6.6.5 |
|
|
Nov. 26 F |
Thanksgiving Holiday
|
|
|
|
|
|
|
|
14 |
Dec. 1 W |
Second Test Ð 9:30 AM Ð 11:10 AM |
|
|
|
Dec. 3 F |
Course
and Performance Review |
|