CELEBREX, VIOXX, ETC.
A good popular review of Celebrex can be found in the June 15, 1998 issue of
the New Yorker magazine, page 32. It's called
"Superaspirin" by Jerome
Groopman. By specifically inhibiting Cyclo-oxygenase 2, or COX-2, scientists
have been able to produce anti-inflammatory drugs which are very powerful
at stopping production of inflammatory prostaglandins, but have very few side
effects. An excellent overview of these drugs, with structures, can be found
in Lancet, Vol 353, Jan 23 '99, page 307-314, by C. J. Hawkey. Celebrex from
Searle, Vioxx from Merck, and Dup 697 from Dupont share a "6-5-6" structure
in which two six membered rings are attached (but not fused) to "ortho" or
adjacent corners of a five membered ring. In Celebrex, the 5 membered ring
is pyrazole (two N's, adj.) See structure below.
In Vioxx, it's thiophene (one S). Dup 697 has
a lactone, which could be called furanone (one O). Nimesulide or Mesulide
has 2 six membered rings (no 5), and Meloxicam has a thiazole ring attached
to a 6:6 fused ring system. Here are some internet references:
is the name used in England.
- FDA approval was speedy
- Arthritis will be a major use of the new drugs.
- More about Arthritis
Other drugs used against Arthritis
Vioxx is a similar drug, from Merck.
- Meloxicam is
another drug in the class.
article about "super painkillers"