FD note - Because you have studied 2,4 DNP you know what a bad idea it would be to ingest the stuff. I present this piece from a men's magazine as a cautionary warning. DNP also may be carcinogenic. DNP article


By Derek Cornelius

Imagine sitting at home on your sofa, watching your favorite TV show and taking a pill. As you relax, the chemicals in the pill start to work and something fantastic happens within your body. Your muscles become harder and stronger, your fat begins to disappear, and you suddenly notice a surge of energy and vitality. What's going on? You're obtaining the same results from the pill that you used to get from doing a lot of hard work and exercise.

Obviously, the above is not possible yet, but we are getting quite a bit closer to the reality every day. Although we can't duplicate with chemicals all the effects of exercise, we can simulate some of the benefits through new, very innovative technology - namely, chemical compounds that have the ability to increase your metabolism drastically, "work" your muscles, and burn a great deal of body fat. The result is a leaner, harder, stronger more fit body.

D.N.P. and dynamite.
The whole concept of chemical exercise took shape for me nearly a year ago, while I was researching the compound 2,4-dinitrophenol (D.N.P.). This amazing phenol was discovered in the 1800's, when it was used mainly in the manufacture of dynamite. Back then, little though was given to the way D.N.P. might interact with biological processes. There were also no regulatory agencies like the Occupational Safety and Health Administration to monitor the handling of dangerous or toxic compounds, so a number of workers in dynamite-manufacturing facilities used D.N.P. freely - no gloves, no respirators, nothing.

These workers began building up considerable quantities of D.N.P. in their bodies, both through skin contact and by inhaling the compound's vapors. At first the workers' symptoms were mild: sweating, light fever, increased appetite, insomnia. Then, as the days passed, the D.N.P. levels in their bodies steadily increased.

It was only a matter of time before those affected began developing more serious side effects: extreme exhaustion, sleeplessness, profuse sweating, high fever, disorientation. A few of these men died. Upon investigation, very high levels of D.N.P. were found in their bodies. The cause of death was specified as D.N.P. poisoning.

D.N.P. is so potent that even if a little bit is absorbed through the skin or inhaled, it can cause significant damage, especially when this occurs day after day. Reports of early poisonings prompted further study of D.N.P. Although the process wasn't clear at the time, researchers knew that D.N.P. was causing hyperacceleration of the human metabolism. Basically, the doomed workmen's bodies were expending too much energy too fast.

D.N.P. and weight loss
By the early 1900's some researchers hit upon the bright idea that because D.N.P. greatly increased the metabolism, it might be an effective tool for burning off excessive weight. They experimented with varying dosages and carefully monitored the effects on groups of people who were both fat and lean. Without exception, D.N.P. greatly speeded up their metabolism - sometimes to twice or more the normal rate.

Once a workable dosage-to-effect ratio was established, D.N.P. began to be put on the market as a surefire remedy for obesity. A lot of promises were made, and, wonder of wonders, the promises came true. Persons taking D.N.P. lost significant amounts of weight in a short period of time; some adhered to a lower dosage just to stay lean and lithe.

Unfortunately, some people decided that if a little was good, a lot would be better. This reckless thinking brought a sure end to D.N.P. sales in the United States. High dosages generated negative side effects, and negative side effects generated negative headlines. Not long afterward, the newly formed Food and Drug Administration put a halt to the selling of D.N.P. in the United States for the purpose of bringing about weight loss.

Who would have guessed then that we would now be studying a fat-loss technology that was first hit upon more than a half century ago? Or that pharmaceutical companies over the past several years would have been spending millions of dollars trying to improve the safety and efficiency of D.N.P. for weight loss?

This writer's experience with D.N.P. began about a year ago, when several friends and I experimented with a reasonable dosage. Within a few hours of the first intake, we all began to feel a little hot and sweaty. As time passed, we became restless and tired - even to the point of feeling out of breath. After two weeks we had each lost from seven to ten pounds.

This was pretty good in itself but the story gets better, much better. During the following three days, something totally unexpected occurred: We human guinea pigs, myself included, gained three to five pounds each - and in lean body mass, not fat. Furthermore, when we returned to the gym, each of us maintained or increased his strength.

Classical uncouplers
These results intrigued me to the point that I began to do in-depth research on D.N.P. and the mechanism behind its extraordinary metabolism-increasing effect. My findings were quite complex. D.N.P. is what is known as a "classical uncoupler." In other words, the energy from the oxidation is funneled through a variety of chemical reactions, or coupling sites, until finally A.T.P. - adenosine triphosphate, the high-energy molecule the body uses for fuel - is formed.

Imagine for a moment many pipes coupled end to end via valves. Imagine all of these connected to a water supply. When the water is turned on, it will move through the pipe until it reaches a valve. If the valve is open, the water will continue to flow. Closing the valve blocks the flow of water.

On the other hand, if a hole has been punched in the pipe at one of the joints, water will burst out and be wasted. To keep the same amount of water flowing through the pipe beyond the hole, you would have to increase the input of water at the source.

Something analogous happens with the phenomenon known as oxidative phosphorylation and uncoupling. The "pipes" are chemicals, the "water" is energy, and the "valves" are the electrons (energy) where the chemical reactions occur. In essence, an uncoupler pokes a hole in the chemical pipeline...

FD Note -- I have omitted further more or less nonsensical discussion. Beware that while DRUGS can be regulated, the first amendment means that WORDS can not, and anyone can publish anything.