Back to everybody Thirumurugan Rathinasabapathy
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Thirumurugan Rathinasabapathy

Education:

Ph. D.2005Medicinal Chemistry, BITS, Pilani, India.
M. Pharm.2000Pharmaceutical Chemistry, BHU, Varanasy, India.
B. Pharm.1997Pharmaceutical Sciences, Madurai Medical College, Tamil Nadu, India.

Research Experience:

  • Drug design - Lead optimization of transcriptional modulators (anticancer activity).

  • Multi-step synthesis of heterocyclic compounds, drug intermediates, molecular scaffolds for libraries. Process development for known compounds for large scale production and planning new routes for unknown compounds.

  • Isolation and characterization of natural products from plant sources.

Honors and Fellowships:

2003 - 2004Senior research fellowship from the Council of Scientific and Industrial Research (CSIR), India.
1998 - 2000Junior research fellowship from the University Grant Commission (UGC), India.
1998Qualified in GATE 1998 examination with 97.11 percentile (All India Rank - 64).

Publications:

  1. D. Sriram, P. Yogeeswari, R. Thirumurugan, P. Roheeth Kumar. Discovery of newer antitubercular oxazolyl thiosemicarbazones. J. Med. Chem., 49, 3448 - 3450, 2006.

  2. R. Thirumurugan, D. Sriram, J. P. Stables, A. Saxena, P. Yogeeswari. 2,4-Dimethoxyphenyl semicarbazones with anticonvulsant activity against three animal models of seizure, synthesis and pharmacological evaluation. Bioorg. Med. Chem., 14, 3106 - 3112, 2006.

  3. P. Yogeeswari, D. Sriram, J. V. Raghavendran, R. Thirumurugan, S. Induja, J. P. Stables. Synthesis and structure-activity relationship on anticonvulsant arylsemicarbazones. Med. Chem., 2, 55 - 62, 2006.

  4. P. Yogeeswari, R. Thirumurugan, D. Sriram, L. R. J. Sunil Jit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J. P. Stables. Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA-mediated mechanism. Acta Pharm., 56, 259 - 272, 2006.

  5. P. Yogeeswari, D. Sriram, R. Thirumurugan, T. R. Bal. Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: An Uptate. Nat. Prod. Res., 20, 497 - 505, 2006.

  6. P. Yogeeswari, D. Sriram, R. Thirumurugan, J. V. Raghavendran, K. Sudhan, J. P. Stables. Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants effective against various animal models of seizure with GABA-T inhibitory activity. J. Med. Chem., 48, 6202 - 6211, 2005.

  7. P. Yogeeswari, D. Sriram, J. Vaigunda Raghavendran, R. Thirumurugan. The GABA shunt: An attractive and potential therapeutic target in the treatment of epileptic disorders. Curr. Drug Metabolism, 6, 127 - 140, 2005.

  8. P. Yogeeswari, D. Sriram, V. Veena, R. Kavya, K. Rakhra, S. Mehta, J. Vaigunda Ragavendran, R. Thirumurugan, J. P. Stables. Synthesis of novel aryl semicarbazones as potential anticonvulsant agents. Biomed. Pharmacother., 59, 51 - 55, 2005.

  9. D. Sriram, P. Yogeeswari, R. Thirumurugan, T. R. Bal. Camptothecin and its Analogues : A review on their chemotherapeutic potential. Nat. Prod. Res., 19, 393 - 412, 2005.

  10. P. Yogeeswari, D. Sriram, R. Thirumurugan, R. Kavya, S. Samuel, J. P. Stables. 3-Chloro-2-methyl phenyl semicarbazones; synthesis and anticonvulsant activity. Eur. J. Med. Chem., 39, 729 - 734, 2004.

  11. D. Sriram, P. Yogeeswari, R. Thirumurugan. Antituberculous activity of some aryl semicarbazone derivatives. Bioorg. Med. Chem. Lett., 14, 3923 - 3924, 2004.

  12. P. Yogeeswari, J. Vaigunda Raghavendran, R. Thirumurugan, A. Saxena, D. Sriram. Ion channels as important targets for antiepileptic drug design. Curr. Drug Targets, 5, 589 - 602, 2004.

  13. P. Yogeeswari, D. Sriram, V. Saraswat, J. Vaigunda Raghavendran, M. Mohan Kumar, S. Murugesan, R. Thirumurugan, J. P. Stables. Synthesis and anticonvulsant and neurotoxicity evaluation of N4 - phthalimido phenyl (thio) semicarbazides. Eur. J. Pharm. Sci., 20, 341 - 346, 2003.

  14. P. Yogeeswari, D. Sriram, A. Brahmandam, I. Sridharan, R. Thirumurugan, J. P. Stables. Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism. Med. Chem. Res., 12, 57 - 68, 2003.

  15. R. Thirumurugan, S. Kavimai, R. S. Srivastava. Anti-tumour activity of Rhinacanthone against DaltonÕs Ascitic LymphomaÓ, Biol. Pharm. Bull., 23(12), 1438 - 1440, 2000.

Abstracts:

  1. R. Thirumurugan, D. Sriram, P. Yogeeswari. Design and synthesis of novel aryl semicarbazone derivatives as anticonvulsants with GABA and glycine mediated mechanism. International symposium on drug discovery and process research, Shivaji University, Kolhapur - 416004, January 23 - 25, 2003.

  2. J. Vaigunda Ragavendran, R. Thirumurugan, I. Sridharan, D. Sriram, P. Yogeeswari. 4-Amino butyrate amino transferase (GABA-T) inhibition as a possible mechanism of some novel anticonvulsant aryl semicarbazones. 55th Indian Pharmaceutical Congress, Chennai, December, 19 - 21, 2003.

  3. R. Kavya, R. Thirumurugan, D. Sriram, P. Yogeeswari. Pharmacological evaluation of aryl(heteroaryl) semi(thio)carbazones for CNS activity. 55th Indian Pharmaceutical Congress, Chennai, December 19 - 21, 2003.

  4. I. Sridharan, B. Archana, R. Thirumurugan, P. Yogeeswari, D. Sriram. γ-aminobutyric acid (GABA) level studies on novel anticonvulsant compounds in rat brain tissue preparation. 54th Indian Pharmaceutical Congress, Pune, December 13 - 15, 2002.

  5. K. Jyothi Mallika, R. Thirumurugan, N. S. Chakravarthy, P. Yogeeswari, D. Sriram. Tetrahydro-2H-1,3,5-thiadiazine-5-(4-Pyridyl carboxamide)-2-thione derivatives as prodrugs for isoniazid: synthesis and antituberculous activity. 54th Indian Pharmaceutical Congress, Pune, December, 13 - 15, 2002.