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Research: The Bruch's Membrane

Adapted from Yuan X, et al. Mol Cell Proteomics. Jun 2010; 9(6): 1031–1046.

The Bruch's Membrane is an acellular fibrous membrane that comprises the blood-retinal barrier. During macular degeneration, a leading cause of blindness, this structure becomes damaged. The synthetic polymer polyethylene glycol (PEG) has mechanical properties that can be designed to mimic many soft tissues. In addition, this polymer can be functionalized with specific biological factors. Current efforts are focusing on developing a tissue engineered Bruch's Membrane using PEG as a scaffold.



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