Shapses, Sue A.
Ph.D., Columbia University, 1988
Department of Nutritional Sciences, School of Environmental and Biological Sciences, New Brunswick; Rutgers
Areas of Interest
Osteoporosis, Obesity, Metabolism, Biochemistry.
Nutritional Aspects of Disease, Clinical Issues in Research, Bone Biology, Perspectives in Grant Writing.
Memberships and Professional Service
American Physiological Society (Membership Committee 1994-97, Chair, Membership Committee 1997-2000); American Society for Nutrition; Editorial Board, Journal of Nutrition - New Members Committee, 1998-2005; American Society for Bone and Mineral Research; American Dietetic Association (and N.J. Chapter); American Society for Clinical Nutrition; American Society for Enteral and Parenteral Nutrition (ASPEN); N.J. Chapter of ASPEN (President, 1996-1997, and Director-at-Large, Science and Education, 1993-1995 and 1998-2005); Experimental Biology and Medicine, Editorial Board; N.J. Bone & Cartilage Group, Director, Initiated and formed this group in 2000, Co-Director from 2005; NJ Obesity Group, Director since 2001 (web: http://nutrition.rutgers.edu/njog/); Co-Director from 2005; Interagency Council on Osteoporosis (New Jersey State Dept of Health and Human Services), Chair, Nominating committee, Co-Chair of the Medical and Scientific Subcommittee, 1999-present , Nominators committee, 2006-present; Elected member of the Food and Nutrition Board: Dietary Reference Intakes
for Vitamin D and Calcium at the Institute of Medicine, National Academy of
Sciences. 2009-2010 http://www.iom.edu/CMS/3788/61170.aspx.
Grants, Honors, and Awards
Academic Excellence Award for Research Program, Rutgers University (Cook), 2003; Award, Outstanding Contribution in New Jersey Interagency Council on Osteoporosis, 2000; Academic Professional Excellence Award for Excellence in Teaching, Rutgers University (Cook), 1999; Assoc for Women in Science Education Foundation Predoctoral Recognition Award for my PhD student, 1999; Johnson and Johnson Discovery Award for Innovative Research, with R Sherrell, 1997; National institutes of Health Grant Title: “Nutritional regulation of bone turnover” 2005-2011; Johnson & Johnson Block Grant, Obesity Prevention and Treatment, 2005-2007; Busch Biomedical Award, Bone quality and hormonal changes due to a low carbohydrate, high protein diet, 2005-07; Raisz-Drezner Award for student, C. Riedt, from the American Society for Bone Mineral Research, 2005; Award, Outstanding Contribution in New Jersey Interagency Council on Osteoporosis, Department of Health and Senior Services, 2000.
Academic Interests and Plans
The research program in my lab focuses on the nutritional regulation of skeletal tissues by examining bone turnover, mass and quality in human trials. In addition, we examine the biochemistry and gene expression within the extracellular matrix (proteoglycans and collagen). Importantly, our studies address how nutritional intake influences the development of osteoporosis using imaging techniques such as DXA , pQCT and uCT. The major focus in the laboratory is to determine how loss of body weight contributes to the risk of osteoporosis. Evidence shows that subjects who diet and lose weight also lose bone. Our goal is to determine mechanisms that regulate the rate of bone turnover and bone loss during caloric restriction. Bone turnover is measured in the urine and blood (e.g., pyridinium cross-links, serum osteocalcin) using techniques of spectrophotometry, HPLC, and radioimmunoassay. Calcium absorption (using stable isotopes and mass spectrometry) and bone-regulating hormones are examined in these studies to address mechanisms of regulation. In addition, studies examining gastric bypass patients are in progress to understand how obesity surgery influences calcium homeostasis and bone mass. Due to the high rate of morbidity and mortality associated with osteoporotic fractures, we also use rodent models to better understand how nutrition regulates bone turnover, composition, and biomechanical properties. In addition, there is an interest bone turnover during disease states. For example, we have studied how glycemic control and hormones regulate bone turnover in insulin-dependent patients with diabetes. In addition, the role of lipids and chemokines in the regulation of bone are being addressed in the laboratory.