Associate Research Professor
Ph.D., Texas Women's University, 1985
Professional Summary/CV [.PDF]
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, New Brunswick; Rutgers
Areas of Interest
The Effects of Hepatotoxic Agents (such as lipopolysaccharide) and Drugs (such as acetaminophen) on Hepatocytes, Liver Macrophages and Endothelial Cells.
Immunology, General Pharmacology, Cellular Immunology, Pathophysiology, Advanced General Toxicology, Advanced Microbiology, Pharmacology.
Memberships and Professional Service
New York Academy of Sciences; Society for Leukocyte Biology; Sigma Xi ‑ Scientific Research Society; Iota Sigma Pi ‑ Woman's Chemistry Honor Society; Microscopy Society of America; Society for Toxicology.
Grants, Honors, and Awards
ARole of Kupffer Cells in Chemical Toxicity, co-investigator, PHS NIH-NIHGMS, 5/1/06-4/30/10; ARole of Collagens Type XII and XIV in Carbon Tetrachloride Induced Liver Fibrosis, Exploratory Research Award, EOHSI, 4/1/99-3/31/00; ARole of Kupffer Cells in Chemical Toxicity, co-investigator, PHS NIH-NIHGMS, 4/1/98-3/31/02; Graduated Cum Laude, State University College at Potsdam, New York, May 1978.
Academic Interests and Plans
My primary research involves studies on the effects of hepatotoxic agents, such as lipopolysaccharide, and drugs, such as acetaminophen on hepatocytes, liver macrophages and endothelial cells. This involves characterizing these cells which are isolated from the liver of rats and mice and analyzing their functional responsiveness to various immunostimulatory compounds including cytokines and endotoxin in vitro. In further studies on modulating the immune response to hepatotoxicants involving the use of knockout mice, I wish to determine which mediators may be responsible for the toxicity caused by our test compounds. Another aspect of my research is focused on analyzing the mechanisms underlying macrophage activation and hepatotoxicity. This work involves analysis of the role of transduction factors in the functioning of hepatocytes, liver macrophages and endothelial cells.