Phone: 732-932-8165, ext. 105
Ph.D., Cornell University, 1989
Department of Animal Sciences, School of Environmental and Biological Sciences, New Brunswick; Rutgers
Areas of Interest
Lactational Physiology, Endocrine Regulation of Cell Growth.
Biotechnology, Animal Science.
Memberships and Professional Service
Member of Association for the Advancement of Science, The Endocrine Society, American Society of Animal Science, International Society for Insulin-like Growth Factor; Editorial Board, Journal of Animal Science, Growth and Development Section; Milk Synthesis Committee, American Daily Science Association.
Academic Interests and Plans
Research in my laboratory focuses on the role of the insulin-like growth factors (IGF) in mammary gland growth and development. A specific focus is to understand the molecular and cellular mechanisms by which these growth factors regulate growth, differentiation and cell survival of mammary epithelial cells. This cell type is responsible for milk synthesis and is also a common site of origin of mammary carcinoma. The IGFs associate with a family of high-affinity binding proteins (IGFBP) which modulate their biological activity. For example we have found that IGF-I specifically stimulates the synthesis of IGF binding protein-3 by mammary epithelial cells. When these cells are transfected to overexpress this protein, they exhibit enhanced responsiveness to IGF-I in terms of DNA synthesis. We are currently investigating the mechanisms underlying this observation.