Professor II; Director, Protein Data Bank
Ph.D., University of Pittsburgh, 1967
Professional Summary/CV [.PDF]
Department of Chemistry and Chemical Biology, School of Arts and Sciences, New Brunswick; Rutgers
Areas of Interest
Structural Biology, Bioinformatics, Protein-Nucleic Acid Interactions.
Helen and members of the Pittsburgh lab, 1965, L to R, D. Zaharias, G. Jeffery & son, R. Shiono & daughter.
Grants, Honors, and Awards
Distinguished Lecturer, Sigma Xil, 2007-2009; M.J. Buerger Award, 2006; Distinguished Service Award, Biophysical Society, 2000; Board of Governors Professor of Chemistry and Chemical Biology; Director, Protein Data Bank; Fellow, American Association for the Advancement of Science; Fellow of the Biophysical Society.
Academic Interests and Plans
Our goals are to understand the structural properties of biological molecules and to relate these structures to their biological functions. Toward these goals, we study the structures of protein-nucleic acid complexes in order help to explain the principles that underlie interactions between nucleic acids and proteins, as well as to increase our understanding of the role of water in mediating intermolecular interactions.
We have also established a program in structural bioinformatics. A key focus of this work has been to establish methods to collect, archive, and analyze structural data. In 1991, we created the Nucleic Acid Database (NDB). In October 1998, the management of the Protein Data Bank (PDB) was moved to the Research Collaboratory for Structural Bioinformatics, of which Rutgers is the lead site.