Bagnell, Carol A.
Phone: 732-932-8165, ext. 102
Ph.D., Medical College of Georgia, 1983
Professional Summary/CV [.PDF]
Department of Animal Sciences, School of Environmental and Biological Sciences, New Brunswick; Rutgers
Areas of Interest
Reproductive endocrinology, control of reproductive tissue growth and remodeling, role of milk-borne factors in neonatal development.
Animal Science, Animal Nutrition, Animal Reproduction, Preveterinary Clinical Anatomy.
Memberships and Professional Service
Division of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, NJ, Fall, 2001&2002; Editorial Board, Reproductive Biology and Endocrinology 2002-Present; Member of American Association for the Advancement of Science, Endocrine Society, Sigma Xi, Society for the Study of Reproduction, Women in Endocrinolog.
Grants, Honors, and Awards
Co-Princpal Investigator, US Department of Agriculture Competitive Grants: "Motritional molecular makers and mediators of porcine reproductive tract development, 2007-2010; Co-Principal Investigator, NJAES Equine Initiative Funding: "Effects of nutritional supplements on exercise-induced inflammation and oxidative stress in horses", 2007-2008; Graduate Program Service Award, Department of Animal Sciences, Rutgers University, 2004.
Academic Interests and Plans
Studies in my laboratory focus on the physiology of the hormone relaxin in the control of female reproductive tract development and remodeling. Relaxin, a member of the insulin-like family of hormones, has long been regarded as a hormone of pregnancy known for its trophic and connective tissue remodeling actions in the female reproductive tract that facilitate delivery at term and prepare the mammary gland for lactation. However, studies show that relaxin is not only a hormone of pregnancy but has multiple roles in non-pregnant animals and targets both reproductive and non-reproductive tissues. In fact, recent studies show that a developmentally-regulated, estrogen-sensitive relaxin receptor system is present in the porcine uterus and cervix from birth. In addition, porcine milk contains relaxin that is transmitted into the peripheral circulation of neonates only if they are allowed to nurse. These studies indicate that a window of opportunity for transmission of milk-borne relaxin from mother to neonate is open during the first few days of life. Thus, factors, such as relaxin, with the potential to control reproductive tract development during early postnatal life are communicated to the neonate in milk by way of a maternally driven ‘lactocrine’ mechanism.