We investigated the region of an ongoing collision between the Indian and Eurasian tectonic plates that results in widespread deformation of the continental lithosphere. Over the past decade numerous regional studies were conducted between the Himalaya and the Tien Shan mountains, each illuminating a small part of the area. We combined the data from a number of portable and permanent networks to construct an ~1800 km long profile of the lithospheric properties across three very different tectonic domains: the Tibetan plateau, the Tarim basin, and the Tien Shan mountains. We used records of distant earthquakes to construct receiver function gathers for each station. The uniformity of processing ensures that our results are comparable along the transect. We examined receiver function gathers at each site, and ranked their quality on the basis of the number of records, noise levels, and directional stability of the wavefield. We selected 32 sites with high-quality data. For these we constructed average receiver function traces using data in 60°-85° distance range, and used them as a guide to the lithospheric layering beneath the region. On most receiver functions we have constructed the most prominent feature is a positive phase likely associated with the crust-mantle transition. The timing of this phase varies significantly over the length of the profile. Beneath the Tibetan plateau delay times ~7-8 s are seen close to the Himalayas, and nearly 10 s delays are found further north. Delays of 6 to 8 s are seen beneath sites in the Tarim basin and the Tien Shan mountains, and a nearly 10 s delay are seen at the border between them. In addition to the pulse associated with the crust-mantle transition we see other locally-consistent features, for example a negative phase with delay values between 3 and 5 s beneath much of the Tibetan plateau.