Abstract:
This article reviews the functions and characteristics of dermatologic vehicles and their influence on topical therapy. Skin products are complex, highly structured systems containing a drug plus a variety of so -called inactive ingredients that stabilize the product and support functionality. In addition to making drug(s) available for absorption into the skin, the vehicle plays a role in therapy through its specific physical properties. Proper formulation requires choosing a vehicle type and components to satisfy disparate requirements. These include bioavailability, chemical and physical stability, freedom from contamination, and patient acceptability. Product quality and effectiveness cannot be judged merely from knowledge of the drug and its concentration.